Evidence map›Paper›PMID 40035393›Full record

ArticleJournal of medicinal chemistry2025

Design, Synthesis, and Biological Activity of Novel Ornithine Decarboxylase (ODC) Inhibitors.

Chad R Schultz, Bilal Aleiwi, X Edward Zhou, Kelly Suino-Powell, Karsten Melcher, Nuno M S Almeida, Angela K Wilson, Edmund L Ellsworth, André S Bachmann

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chad R SchultzDepartment of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan 49503, United States.
Bilal AleiwiDepartment of Pharmacology and Toxicology, College of Human Medicine, East Lansing, Michigan 48824, United States.
X Edward ZhouDepartment of Structural Biology, Van Andel Institute, Grand Rapids, Michigan 49503, United States.
Kelly Suino-PowellDepartment of Structural Biology, Van Andel Institute, Grand Rapids, Michigan 49503, United States.
Karsten MelcherDepartment of Structural Biology, Van Andel Institute, Grand Rapids, Michigan 49503, United States.ORCID 0000-0002-9125-4027
Nuno M S AlmeidaDepartment of Chemistry, College of Natural Science, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0002-6091-7289
Angela K WilsonDepartment of Chemistry, College of Natural Science, Michigan State University, East Lansing, Michigan 48824, United States.ORCID 0000-0001-9500-1628
Edmund L EllsworthDepartment of Pharmacology and Toxicology, College of Human Medicine, East Lansing, Michigan 48824, United States.
André S BachmannDepartment of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan 49503, United States.ORCID 0000-0002-6510-8560

Funding

Novel ODC Inhibitor Phaseolotoxin in NeuroblastomaR21CA216867 · NCI · MICHIGAN STATE UNIVERSITY · PI BACHMANN, ANDRE S · 2018 to 2019
$453k
NCI NIH HHS R21 CA216867
6 · The paper itself

Abstract

We here describe the design, synthesis, and biological activity of novel ornithine decarboxylase (ODC) inhibitors that show significantly higher potency

Indexed as

Drug DesignOrnithine DecarboxylaseOrnithine Decarboxylase InhibitorsCatalytic DomainCrystallography, X-RayHumansModels, MolecularMolecular Docking SimulationMolecular Dynamics SimulationPolyaminesStructure-Activity RelationshipOrnithine DecarboxylaseOrnithine Decarboxylase InhibitorsPolyamines

Identifiers

PMID40035393
PMCPMC11912471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.