ArticleJournal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie2025
A Similarity Matrix for Preserving Haplotype Diversity Amongst Parents in Genomic Selection.
Article in Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- A comparative study on recombination activity in cattle.Genetics, selection, evolution : GSE · 2026Article
- PyMSQ: a Python package for fast Mendelian sampling (co)variance and haplotype-based similarity in genomic selection.BMC bioinformatics · 2026Article
- Strategies to improve on selection based on estimated breeding values.Genetics, selection, evolution : GSE · 2026Article
- Practical Considerations When Using Mendelian Sampling Variances for Selection Decisions in Genomic Selection Programs.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2025Article
- Prediction of additive genetic variances of descendants for complex families based on Mendelian sampling variances.G3 (Bethesda, Md.) · 2024Article
- Improving selection decisions with mating information by accounting for Mendelian sampling variances looking two generations ahead.Genetics, selection, evolution : GSE · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
In genomic selection, balancing genetic gain with the preservation of genetic diversity is a critical challenge, requiring innovative approaches to parent selection. Traditional methods risk losing valuable genetic diversity by not fully accounting for the complex patterns of haplotype distribution. To address this, we developed a novel haplotype similarity measure that estimates the genetic similarity amongst offspring from parent pairs by analysing segregating marker patterns and the covariance of additive genetic effects between potential parental gametes. This measure is encapsulated in a novel similarity matrix that quantifies parental genetic relationships and their Mendelian sampling variance, facilitating the selection of parents with diverse haplotypes to maintain genetic diversity. Our method was evaluated through simulation studies and empirical data analysis, indicating that the similarity matrix can help preserve haplotype diversity and potentially improve long-term genetic gains compared to traditional selection methods. These results suggest that the similarity matrix could contribute to more efficient and sustainable genomic selection programs, although further research is necessary to fully understand its impact.
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Registered trials
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