ArticleeLife2025
Short-term social isolation acts on hypothalamic neurons to promote social behavior in a sex- and context-dependent manner.
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Article
- Of mice and gender: considering gender norms in rodent models.Biology of sex differences · 2026Review
- Advancing insights into the neuroendocrine basis of socio-sexual interactions in mammals.Endocrinology · 2026Review
- Presence of a home cage running wheel, but not wheel running per se, decreases social motivation in adult C57BL/6J female mice.PloS one · 2026Article
- Oxytocin signaling regulates maternally directed behavior during early life.Science (New York, N.Y.) · 2025Article
- Mountable miniature microphones to identify and assign mouse ultrasonic vocalizations.Cell reports methods · 2025Article
- Comparative Perspectives on Neuropeptide Function and Social Isolation.Biological psychiatry · 2025Review
- Article
- Rates of female mouse ultrasonic vocalizations are low and are not modulated by estrous state during interactions with muted males.Scientific reports · 2025Article
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Social animals, including both humans and mice, are highly motivated to engage in social interactions. Short-term social isolation promotes social behavior, but the neural circuits through which it does so remain incompletely understood. Here, we sought to identify neurons that promote social behavior in single-housed female mice, which exhibit increased rates of social investigation, social ultrasonic vocalizations (USVs), and mounting during same-sex interactions that follow a period of short-term (3 days) isolation. We first used immunostaining for the immediate early gene Fos to identify a population of neurons in the preoptic hypothalamus (POA) that increase their activity in single-housed females following same-sex interactions (POA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.