Evidence map›Paper›PMID 40035241›Full record

ArticleMagnetic resonance in medicine2025

A flexible MRF approach to improve kinetic rate estimation with bSSFP-based hyperpolarized [1-

Anna Bennett Haller, Xiaoxi Liu, Avantika Sinha, Sule Sahin, Peder E Z Larson, Charlie Yi Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna Bennett HallerUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-1911-4190
Xiaoxi LiuRadiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-0657-8922
Avantika SinhaUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.
Sule SahinUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-7006-4793
Peder E Z LarsonUC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0003-4183-3634
Charlie Yi WangRadiology and Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-5495-9546

Funding

TR&D3: Open-Source Tools for Processing Hyperpolarized MR DataP41EB013598 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Daniel B Vigneron · 2011 to 2026
$19.9M
Biomedical Imaging for Clinician ScientistsT32EB001631 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LINK · 2005 to 2026
$5.6M
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor AggressivenessR01CA249909 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL, WANG, ZHEN JANE · 2021 to 2025
$3.2M
Hyperpolarized 13C MRI of Cardiac Metabolic Remodeling in Heart DiseaseR01HL171992 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Maria Roselle Abraham, Peder Eric Zufall Larson · 2024 to 2026
$2.4M
Upgrade of an Obsolete 3.35T DNP Polarizer to enable new HP C-13 Technology DevelopmentS10OD025077 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VIGNERON, DANIEL B · 2020 to 2020
$1.7M
Hyperpolarized Carbon-13 Metabolic MRI of the Human HeartR33HL161816 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ABRAHAM, MARIA ROSELLE, LARSON, PEDER ERIC ZUFALL · 2022 to 2023
$965k
Hyperpolarized 13C Metabolic MRI for Noninvasive Monitoring of Kidney InjuryR21DK130002 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LARSON, PEDER ERIC ZUFALL, WANG, ZHEN JANE · 2021 to 2022
$444k
NCI NIH HHS R01 CA249909NCI NIH HHS R01CA249909NHLBI NIH HHS R01 HL171992NHLBI NIH HHS R33 HL161816NHLBI NIH HHS R33HL161816NIBIB NIH HHS P41 EB013598NIBIB NIH HHS P41EB013598NIBIB NIH HHS T32 EB001631NIBIB NIH HHS T32EB001631NIDDK NIH HHS R21 DK130002NIDDK NIH HHS R21DK130002NIH HHS S10 OD025077University of California, San Francisco
6 · The paper itself

Abstract

purposeIn this work, we adopt the MR fingerprinting (MRF) framework and leverage its flexibility in quantitative pulse sequence design to propose improved balanced steady-state free precession (bSSFP)-based hyperpolarized Carbon-13 (

methodsSpectrally selective bSSFP-based acquisitions with variable RF excitation were implemented for [1-

resultsSimulations indicated that combining bSSFP-based acquisitions and variable RF excitation (MRF-Sigmoid) exhibited bias <0.1% across the majority (86%) of combinations of pyruvate-to-lactate conversion rate (k

conclusionThe use of the MRF framework for k

Indexed as

Image Processing, Computer-AssistedKidneyMagnetic Resonance ImagingPyruvic AcidAlgorithmsAnimalsCarbon IsotopesComputer SimulationKineticsLactic AcidMonte Carlo MethodRatsRats, Sprague-DawleyCarbon-13Carbon IsotopesLactic AcidPyruvic Acid13CbSSFPhyperpolarizedlactatemetabolic imagingMRFMRIpyruvate

Identifiers

PMID40035241
PMCPMC11971489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.