ArticleJournal of veterinary internal medicine
Redox Biomarker Variations With Severity of Asthma in Horses Across Different Sample Types.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Biomarkers of equine asthma: A review of the current literature.Veterinary research communications · 2026Review
- Differences in Redox Biomarkers in Bronchoalveolar Lavage Fluid of Leisure Horses With and Without Severe Equine Asthma: Preliminary Results.Animals : an open access journal from MDPI · 2026Article
- Training and race-induced coordination of oxidative stress markers in racehorses: insights from multivariate and univariate analyses.Journal of veterinary internal medicine · 2026Article
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Authors and funding
5 authors.
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Abstract
backgroundThe contribution of redox imbalance to equine asthma (EA) pathogenesis remains unclear.
objectives(1) validate and measure a panel of redox biomarkers in the tracheal wash (TW) and bronchoalveolar lavage (BAL) samples from horses with neutrophilic and mastocytic mild-moderate EA (MEA) and severe EA. (2) Evaluate the same panel in saliva and serum for comparative purposes. ANIMALS: A total of 117 horses: 37 healthy, 26 mastocytic MEA, 29 neutrophilic MEA, and 25 severe EA.
methodsCross-sectional study using TW, BAL, and serum and saliva sampling. After assay validation, redox biomarkers-ferric reducing antioxidant power (FRAP), Trolox equivalent antioxidant capacity (TEAC), glutathione reductase (GSHred), superoxide dismutase (SOD), and advanced oxidation protein products (AOPP) were quantified.
resultsAssays demonstrated low imprecision, good linearity, and adequate sensitivity in TW and BAL fluid. Bronchoalveolar lavage fluid biomarkers decreased with EA severity for TEAC (healthy horses: median, 0.013; severe EA horses: 0.010; p < 0.001; effect size [ES] = 0.36), SOD (healthy horses: median, 0.95; severe EA horses: 0.70; p < 0.001; ES = 0.39), and AOPP (healthy horses: median, 44.9; severe EA horses: 20; p = 0.05; ES = 0.18). Bronchoalveolar lavage neutrophil differential counts were negatively correlated with saliva SOD (rho = -52; p = 0.001), GSHred (rho = - 0.46; p = 0.01) and AOPP (rho = - 0.34; p = 0.04). CONCLUSIONS AND CLINICAL IMPORTANCE: These findings support the potential of redox biomarkers measured in BAL fluid in the characterization of neutrophilic EA and emphasize their value in guiding antioxidant-based therapeutic strategies. Based on our results, redox imbalance is less evident in mastocytic EA compared with neutrophilic EA.
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