ArticleFrontiers in neuroscience2025
Impacts of night shift on medical professionals: a pilot study of brain connectivity and gut microbiota.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Disrupted Rhythms, Disrupted Microbes: A Systematic Review of Shift Work and Gut Microbiota Alterations.Nutrients · 2025Pooled it
- A Randomized Controlled Crossover Lifestyle Intervention to Improve Metabolic and Mental Health in Female Healthcare Night-Shift Workers.Nutrients · 2025Trial
- Reduced but Reversible Brain Entropy After Occupational Partial Sleep Deprivation in Night-Shift Medical Staff.Brain and behavior · 2026Article
- Gut Microbiota α- and β-Diversity, but Not Dietary Patterns, Differ Between Underweight and Normal-Weight Japanese Women Aged 20-39 Years.Nutrients · 2025Observational
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- HowMedicina (Kaunas, Lithuania) · 2025Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Night shift is a prevalent workstyle in medical hospitals, demanding continuous health monitoring and rapid decision making of medical professionals. Night shifts may cause serious health problems to medical staff, including cognitive impairments, poor sleep, and inflammatory responses, leading to the altered gut-brain axis. However, how night shifts impact gut-brain axis and how long the impact lasts remain to be studied. Hence, we investigated the dynamic changes of brain-microbiota relations following night shifts and subsequent recovery days among medical shift workers. Young medical staffs were recruited for the 3-session assessments over the scheduled night shifts (pre-shift, post-shift, and recovery) by measuring (a) sleep metrics, (b) brain functions, (c) gut bacteriome compositions, and (d) cognitive assessments. Participants experienced partial sleep deprivation only during the 5-day night shifts but rapidly returned to baseline after the 4-day recovery, so as the elevated brain fluctuations in the superior frontal gyrus after night shifts. Meanwhile, the night shifts caused elongated connectivity changes of default-mode and dorsal attention networks without recovery. Nevertheless, we did not find prevailing night-shift effects on cognition and gut bacteriome compositions, except the
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.