ArticleIranian journal of pathology2024
Role of CK7 Immunoreactivity in Predicting Progression of the Cervical Intraepithelial Neoplasia: A Retrospective Cross-sectional Study.
Article in Iranian journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background & Objective: Cervical intraepithelial squamous lesions (SIL) are the first step toward developing most cervical cancers. Moreover, most of the previous studies focusing on a reliable predictive factor of cervical cancer progression have been reported as inconclusive. Recently, immunophenotyping of squamocolumnar junction cells with CK7 has been introduced as a novel SIL detection and risk evaluation method. Therefore, we aimed to investigate the value of CK7 positivity and its pattern in predicting the progression of LSIL to high-grade counterparts. Methods: This retrospective study was conducted in Yas Complex Hospital from 2016 to 2018 among patients of the clinic of colonoscopy. Patients with low-grade lesions were included in one group, and patients with high-grade lesions were considered as a control group. The immunoreactivity of CK7 by immunohistochemical staining pattern was interpreted in both groups. Results: CK7 immunoreactivity was negative in 29.5% of the precancerous lesions and positive in 70.5%. The relationship between grade and CK7 staining was significant ( Conclusion: Our data and previous studies support the correlation of CK7 expression with a higher chance of progression of low-grade intraepithelial lesions.
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