Evidence map›Paper›PMID 40034785›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Interstitial Cystitis: a phenotype and rare variant exome sequencing study: Interstitial Cystitis: a phenotype and exome sequencing study.

Joshua E Motelow, Ayan Malakar, Sarath Babu Krishna Murthy, Miguel Verbitsky, Atlas Kahn, Elicia Estrella, Louis Kunkel, Madelyn Wiesenhahn, Jaimee Becket, Natasha Harris and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Joshua E MotelowDivision of Critical Care and Hospital Medicine, Department of Pediatrics, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.ORCID 0000-0002-4367-4182
Ayan MalakarDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Sarath Babu Krishna MurthyDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Miguel VerbitskyDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Atlas KahnDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Elicia EstrellaDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA.
Louis KunkelDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA.
Madelyn WiesenhahnDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA.
Jaimee BecketDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Natasha HarrisDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Richard LeeDepartment of Urology, Boston Children's Hospital, Harvard Medical School, Boston MA.
Rosalyn AdamDepartment of Urology, Boston Children's Hospital, Harvard Medical School, Boston MA.
Krzysztof KirylukDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Ali G GharaviDivision of Nephrology, Department of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Catherine A BrownsteinDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA.

Funding

Urology Centers Program Interactions Core (U24)U24DK127726 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Kristina L Penniston · 2020 to 2026
$6.3M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI CHEN, CHINFEI · 2016 to 2020
$5.2M
Genetic Risk Underlying Pediatric Critical IllnessK08HG012374 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOTELOW, JOSHUA ETHAN · 2023 to 2025
$633k
NCCDPHP CDC HHS U01 DP006634NHGRI NIH HHS K08 HG012374NICHD NIH HHS U54 HD090255NIDDK NIH HHS U24 DK127726
6 · The paper itself

Abstract

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a poorly understood and underdiagnosed syndrome of chronic bladder/pelvic pain with urinary frequency and urgency. Though IC/BPS can be hereditary, little is known of its genetic etiology. Using the eMERGE data, we confirmed known phenotypic associations such as gastroesophageal reflux disease and irritable bowel syndrome and detected new associations, including osteoarthrosis/osteoarthritis and Barrett's esophagus. An exome wide ultra-rare variants analysis in 348 IC/BPS and 11,981 controls extended the previously reported association with

Identifiers

PMID40034785
PMCPMC11875234

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.