ArticlemedRxiv : the preprint server for health sciences2025
Lipid peroxidation and colorectal cancer risk: a time-varying relationship.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Importance: We recently observed an inverse and time-dependent association between systemic oxidative stress (OxS), measured by urinary biomarkers of nucleic acid oxidation, and colorectal cancer (CRC) risk. Further investigations into other types of OxS markers are warranted. Objective: To extend the investigation into systemic lipid peroxidation and CRC risk. Design Setting and Participants: Utilizing a nested case-control design, this study's primary analysis was performed in two large prospective cohorts in Shanghai, China, and replicated in an independent cohort in the US. Exposures: Systemic lipid peroxidation was assessed by urinary F Main Outcomes and Measures: During 15.1-year follow-up in the Shanghai cohorts, 1938 incident CRC cases were identified and matched to one control each through incidence-density sampling. In the US cohort, 285 incident CRC cases were included, each matched to two controls. Odds ratios (ORs) for CRC were calculated using multivariable conditional logistic regression models. Results: Elevated levels of urinary 5-F Conclusions: This study provides new evidence that systemic OxS is inversely and time-dependently associated with CRC risk in humans. Key Points:
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