Evidence map›Paper›PMID 40034773›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors.

Sophia S Liang, Alyssa R Roeckner, Timothy D Ely, Lauren A M Lebois, Sanne J H van Rooij, Steven E Bruce, Tanja Jovanovic, Stacey L House, Francesca L Beaudoin, Xinming An and 31 more

Abstract readPreprint
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In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors.

Sophia S LiangDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Alyssa R RoecknerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Timothy D ElyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Lauren A M LeboisDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Sanne J H van RooijDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri - St. Louis, St. Louis, MO, 63121, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, 48202, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, RI, 02930, USA.
Xinming AnInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, CA, 94143, USA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, 30332, USA.
Sarah D LinnstaedtInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Laura T GermineInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.
Scott L RauchInstitute for Technology in Psychiatry, McLean Hospital, Belmont, MA, 02478, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, MA, 01655, USA.ORCID 0000-0001-7311-1121
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, MI, 48202, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Sophia SheikhDepartment of Emergency Medicine, University of Florida College of Medicine -Jacksonville, Jacksonville, FL, 32209, USA.
Jose L PascualDepartment of Surgery, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Mark J SeamonDepartment of Surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Erica HarrisDepartment of Emergency Medicine, Einstein Medical Center, Philadelphia, PA, 19107, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, MI, 48236, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Roland C MerchantDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Robert M DomeierDepartment of Emergency Medicine, Trinity Health-Ann Arbor, Ypsilanti, MI, 48197, USA.
Niels K RathlevDepartment of Emergency Medicine, University of Massachusetts Medical School-Baystate, Springfield, MA, 01107, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, MI, 48202, USA.
Paulina SergotDepartment of Emergency Medicine, McGovern Medical School at UTHealth, Houston, TX, 77030, USA.
Leon D SanchezDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA.
John F SheridanDivision of Biosciences, Ohio State University College of Dentistry, Columbus, OH, 43210, USA.
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, MA, 02115, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.
Samuel A McLeanDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27559, USA.
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30329, USA.
E Kate WebbDivision of Depression and Anxiety Disorders, McLean Hospital, Belmont, MA, 02478, USA.
Nathaniel G HarnettDivision of Depression and Anxiety, McLean Hospital, Belmont, MA, 02478, USA.

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Extracellular vesicles as biomarkers of trauma exposure and PTSD riskR01MH129495 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Tracy L Bale, Tanja Jovanovic · 2022 to 2026
$4.0M
Mobile Measures of Threat Sensitivity for Cross-sectional and Longitudinal AssessmentR01MH121617 · NIMH · MCLEAN HOSPITAL · PI GERMINE, LAURA THI · 2020 to 2025
$3.9M
Investigating Fear System Myelination in PTSD Using In Vivo and Post Mortem DataR01MH132617 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI HUBER, BERTRAND R, NEYLAN, THOMAS C · 2023 to 2025
$2.1M
Multimodal characterization of affective visual processing in the early aftermath of traumaK01MH129828 · NIMH · MCLEAN HOSPITAL · PI Nathaniel G Harnett · 2023 to 2026
$719k
Characterizing the Neurobiology of Pathological Dissociation: Mechanisms of Face Perception and Self Referential ProcessingK01MH118467 · NIMH · MCLEAN HOSPITAL · PI LEBOIS, LAUREN ANN MCDONOUGH · 2019 to 2022
$679k
The Biological Cost of External and Internal Resilience Factors in Trauma SurvivorsF32MH134443 · NIMH · MCLEAN HOSPITAL · PI WEBB, ELISABETH KATHLEEN · 2023 to 2023
$69k
NIA NIH HHS R01 AG060477NIMH NIH HHS F32 MH134443NIMH NIH HHS K01 MH118467NIMH NIH HHS K01 MH129828NIMH NIH HHS R01 MH121617NIMH NIH HHS R01 MH129495NIMH NIH HHS R01 MH132617NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

Background: Residential segregation is associated with differential exposure to air pollution. Hippocampus structure and function are highly susceptible to pollutants and associated with posttraumatic stress disorder (PTSD) development. Therefore, we investigated associations between residential segregation, air pollutants, hippocampal neurobiology, and PTSD in recent trauma survivors. Methods: Participants ( Results: Non-Hispanic Black participants lived in neighborhoods with significantly greater segregation and air pollution compared to Hispanic and non-Hispanic white participants ( Conclusion: Residential segregation is associated with greater air pollution exposure, which is in turn associated with variability in hippocampal features among recent trauma survivors. Further research is needed to assess relationships between other environmental factors and trauma and stress-related disorders.

Indexed as

HippocampusMultimodalPollutionSegregationTrauma

Identifiers

PMID40034773
PMCPMC11875236

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