ArticlemedRxiv : the preprint server for health sciences2025
Molecular genetic influences on attentional control and other executive processes and their links with psychopathology in the AFFECT study.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Attentional control is a critical component of executive functioning involved in numerous psychiatric and neurological disorders, yet its etiological relationships with many cognitive and behavioral phenotypes remain underexplored. Methods: We conducted the first multivariate characterization of molecular genetic influences on attentional control and other executive processes in a cohort of more than 20,000 individuals enriched for mood disorders. We used Genomic Structural Equation Modeling to formally model patterns of genetic covariance among these task-based measures of cognition, as well as their relationships with other cognitive, clinical, and imaging-derived phenotypes. Results: We identified two independent latent genetic factors: one broadly influencing executive function and one narrowly influencing attentional control. Both the Conclusions: Overall, the results of our study suggest that genetic influences on attentional control are generally distinct from those that influence broader aspects of executive function. The
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