Evidence map›Paper›PMID 40034697›Full record

ArticleFrontiers in immunology2025

Epigenetic factors and inflammaging: FOXO3A as a potential biomarker of sarcopenia and upregulation of DNMT3A and SIRT3 in older adults.

Diana Bogucka, Anna Wajda, Barbara Stypińska, Marcin Jerzy Radkowski, Tomasz Targowski, Ewa Modzelewska, Tomasz Kmiołek, Adam Ejma-Multański, Gabriela Filipowicz, Yana Kaliberda and 2 more

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Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Diana BoguckaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Anna WajdaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Barbara StypińskaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Marcin Jerzy RadkowskiDepartment of Geriatrics, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Tomasz TargowskiDepartment of Geriatrics, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Ewa ModzelewskaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Tomasz KmiołekDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Adam Ejma-MultańskiDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Gabriela FilipowiczDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Yana KaliberdaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Ewa DudekDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Agnieszka Paradowska-GoryckaDepartment of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Epigenetic factors influence inflammaging and geriatric disorders such as sarcopenia and frailty. It is necessary to develop a biomarker/panel of biomarkers for fast and easy diagnostics. Currently, hard-to-access equipment is required to diagnose sarcopenia. The development of a biomarker/panel of biomarkers will prevent many older adults from being excluded from the diagnostic process. Methods: In this study, we analyzed selected gene expression profiles, namely, Results: We revealed a lower mRNA level of Conclusions: Our study revealed

Indexed as

DNA Methyltransferase 3AEpigenesis, GeneticForkhead Box Protein O3SarcopeniaSirtuin 3AdultAgedAged, 80 and overFemaleGenetic MarkersHumansMaleMiddle AgedMuscle, SkeletalRNA, MessengerUp-RegulationDNA Methyltransferase 3AForkhead Box Protein O3FOXO3 protein, humanGenetic MarkersRNA, MessengerSIRT3 protein, humanSirtuin 3ageingDNMT3AFOXO3AfrailtygeriatricsinflammationsarcopeniaSIRT3

Identifiers

PMID40034697
PMCPMC11872893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.