Evidence map›Paper›PMID 40034647›Full record

ArticlebioRxiv : the preprint server for biology2025

SRS microscopy identifies inhibition of vitellogenesis as a mediator of lifespan extension by caloric restriction in

Bowen Yang, Bryce Manifold, Wuji Han, Catherin DeSousa, Wanyi Zhu, Aaron Streets, Denis V Titov

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bowen YangDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Bryce ManifoldDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.
Wuji HanCenter for Computational Biology, University of California, Berkeley, Berkeley, CA, USA.
Catherin DeSousaDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Wanyi ZhuDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.
Aaron StreetsDepartment of Bioengineering, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0002-3909-8389
Denis V TitovDepartment of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-5677-0651

Funding

OPTICAL, FLUIDIC, AND MOLECULAR TECHNOLOGIES FOR SINGLE-CELL OMICSR35GM124916 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Aaron Streets · 2017 to 2026
$3.4M
Genetically encoded tools for manipulation of metabolism in vivoDP2GM132933 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI TITOV, DENIS VASILIEVICH · 2018 to 2018
$2.4M
NIGMS NIH HHS DP2 GM132933NIGMS NIH HHS R35 GM124916
6 · The paper itself

Abstract

The molecular mechanisms of aging are not fully understood. Here, we used label-free Stimulated Raman scattering (SRS) microscopy to investigate changes in proteins and lipids throughout the lifespan of

Identifiers

PMID40034647
PMCPMC11875241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.