Evidence map›Paper›PMID 40034604›Full record

ArticleTherapeutic advances in medical oncology2025

Ferroptosis-related genes as prognostic markers for survival and immunotherapy in triple-negative breast cancer: analysis of public databases and a single institution.

Yizhao Xie, Zhonghua Tao, Biyun Wang, Yannan Zhao, Xinyu Chen, Bin Li, Jinyan Wang, Guangliang Chen, Xichun Hu

Abstract read
In one paragraph

Article in Therapeutic advances in medical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yizhao XieDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Zhonghua TaoDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.ORCID https://orcid.org/0000-0003-3975-3803
Biyun WangDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.ORCID https://orcid.org/0000-0002-7829-1544
Yannan ZhaoDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Xinyu ChenDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Bin LiDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Jinyan WangDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Guangliang ChenDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.
Xichun HuDepartment of Medical Oncology, Fudan University Shanghai Cancer Center, 270 Dongan Road, 200032, Shanghai, China.ORCID https://orcid.org/0000-0001-6148-9186

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ferroptosis plays a vital role in cancer development and treatment. The relationship between ferroptosis-related genes and breast cancer prognosis, as well as immunotherapy outcomes, remains unknown. Objectives: To evaluate the prognostic value of ferroptosis-related genes in breast cancer. Methods: We conducted differential expressions and prognostic analysis for ferroptosis-related genes on public databases and breast cancer patients in our center and analyzed their predictive value for immunotherapy of breast cancer patients. Results: We identified prognostic ferroptosis-related genes, constructed a nomogram, and validated key genes using patient data from our center. We also investigated ferroptosis-related genes significantly associated with immune infiltration and identified Conclusion: Ferroptosis-related genes had potential prognostic value and predictive value for breast cancer immunotherapy.

Indexed as

breast cancerferroptosisimmunotherapyprognosis

Identifiers

PMID40034604
PMCPMC11873862

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.