ArticleRegenerative therapy2025
Zinc sulfate gel reshapes the wound microenvironment to promote full-thickness wound healing in mice.
Article in Regenerative therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Review
- The Zinc-Senescence Axis in Skin Aging and Wound Healing: A Narrative Review.International journal of molecular sciences · 2026Review
- Synthesis and characterization of a new N4-Schiff base its zinc halide/pseudohalide complexes with thermal, antimicrobial, antioxidant, anticancer, DNA cleavage and wound healing properties.Scientific reports · 2026Article
- Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026Review
- Optimized spray-drying of zinc sulfate-loaded liposomes: physicochemical characterization and in vitro release assessment.Scientific reports · 2025Article
- Osteonecrosis of the Jaw in Post-Bariatric Patients: An Underestimated Risk in Oral Surgery? Clinical Implications and Perspectives.Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric DentistryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delayed healing of skin wounds significantly impacts human life, Zinc plays a pivotal role in human growth, the immune system, and various cellular processes. Previous studies have demonstrated that zinc supplementation or topical zinc ion therapy can accelerate wound healing in cases of skin injury. Zinc deficiency has been linked to delayed wound healing, but the role it plays remains to be elucidated. In this study, we report the preparation of zinc sulfate gel to promote wound healing by treating inflammation, antioxidant effects, and angiogenesis. We demonstrated the efficacy of zinc sulfate gel in wound healing in a mouse model of full-thickness skin excision, spared the anti-inflammatory and antioxidant capabilities of zinc ions. Furthermore, Zinc sulfate gel can stimulate tissue to enter the proliferative phase by regulating macrophage polarization, thereby accelerating collagen deposition, granulation tissue formation, and extracellular matrix production and remodeling. In conclusion, zinc ion gel provides a promising strategy for skin wounds regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.