ArticleAnimal nutrition (Zhongguo xu mu shou yi xue hui)2025
Increased proline intake during gestation alleviates obesity-related impaired fetal development and placental function in gilts.
Article in Animal nutrition (Zhongguo xu mu shou yi xue hui), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Excess backfat deposition and restricted feeding in gestating sows: An overview of mechanisms compromising their health and performance, and regulatory effects of functional dietary fibers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Amino Acid Restriction Impairs Human Endometrial Stromal Cell Decidualization and Is Rescued by Proline Supplementation.Journal of cellular and molecular medicine · 2025Article
- Proline-driven metabolic reprogramming promotes skeletal muscle hypertrophy and oxidative myofiber specification in porcine offspring: a stage-optimized maternal nutritional intervention.Journal of animal science and biotechnology · 2025Article
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13 authors.
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Abstract
Maternal proline (Pro) supplementation enhances fetal survival and placental development in mice. However, the effect of Pro on fetal and placental development in gilts remains to be investigated, particularly in the context of obesity-induced impaired pregnancy. Here, we investigated the effect of dietary Pro on fetal and placental development in obese gilts. Exp.1: On day 60 of gestation, 48 gilts with similar delivery times were selected and followed up until delivery to determine the relationship between maternal obesity, litter performance, and Pro abundance in term placentae. The results showed that impaired reproductive performance was associated with body condition parameters and inadequate placental Pro availability of gilts. Exp. 2: A total of 114 gilts were then used in a 2 × 3 factorial design to investigate the interaction between body condition (factor I: normal or obese gilts) and dietary Pro levels (factor II: low [0.89%, L-Pro], medium [1.39%, M-Pro], and high [1.89%, H-Pro]) on farrowing performance and placental angiogenesis. This resulted in six treatment combinations: normal-L-Pro, obese-L-Pro, normal-M-Pro, obese-M-Pro, normal-H-Pro, and obese-H-Pro. The effective number of replicates per group was 17, 21, 19, 21, 18, and 18, respectively (1 gilt per replicate). The results showed that increasing Pro intake increased piglet birth weight (
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