ArticleFrontiers in cellular and infection microbiology2025
Assessing mutation accumulation in DNA repair-deficient
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Methods: This study investigated mutation rates in Results: Mutation rates were significantly higher in repair-deficient isolates, exceeding typical cgMLST thresholds currently used in Conclusions: The standard 7-allele cgMLST threshold effectively identifies related strains in most cases, but may require adjustments for hypermutator strains. Incorporating DNA repair data could improve the accuracy of outbreak investigations, ensuring reliable public health responses.
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