Evidence map›Paper›PMID 40034286›Full record

ArticleHeliyon2025

Diphlorethohydroxycarmalol inhibits Müller cell gliosis by disrupting CXCR4/CXCL12 interaction in violet-blue light-induced retinal phototoxicity.

Myeongjoo Son, Dineth Pramuditha Nagahawatta, Hang-Chan Jo, You-Jin Jeon, Bomi Ryu, Dae Yu Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Myeongjoo SonDepartment of Anatomy & Cell Biology, School of Medicine, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Dineth Pramuditha NagahawattaDepartment of Marine Life Sciences, Jeju National University, Jeju, 63243, Republic of Korea.
Hang-Chan JoCenter for Sensor Systems, Inha University, Incheon, 22212, Republic of Korea.
You-Jin JeonDepartment of Marine Life Sciences, Jeju National University, Jeju, 63243, Republic of Korea.
Bomi RyuMajor of Food Science and Nutrition, Pukyong National University, Busan, 48513, Republic of Korea.
Dae Yu KimCenter for Sensor Systems, Inha University, Incheon, 22212, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Müller gliosis is a complex process that impairs the ability of retinal Müller glial cells to respond to various forms of retinal injury or disease, leading to retinal damage. Blue light (BL) exposure is a known cause of retinal damage. In this study, we aimed to investigate the potential of DPHC in inhibiting Müller gliosis in models of BL-exposure. We conducted in silico binding analysis to evaluate the binding of DPHC to CXCR4. Then, we developed in vitro and

Indexed as

CXCR4 signalingDiphlorethohydroxycarmalol (DPHC)Müller gliosisRetinal Müller glial cellsRetinal phototoxicityViolet-blue 405 nm light

Identifiers

PMID40034286
PMCPMC11874561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.