ArticleBiochemistry and biophysics reports2025
Prediction of the Co-receptor usage of the main worldwide HIV-1 subtypes, CRF, and CRF35-AD in Iranian patients via the five genotypic tools.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- High prevalence of baseline Non-R5 viral tropism in PLWH is associated with immune damage: a systematic review and meta-analysis.Frontiers in immunology · 2025Pooled it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV-1 has various subtypes and CRFs, each with unique genetic attributes that impact the virus's spread, disease development, and response to treatment in different populations. Determining V3 tropism is crucial for utilizing CCR5 antagonists and understanding why certain HIV-1 subtypes are more pathogenic than others are. Genotypic coreceptor usage of 603 major subtypes of A, B, C, AE, and CRF35-AD is investigated via five bioinformatics tools (PhenoSeq, WebPSSM, Geno2Pheno, Net charge, and the 11/25 rule). This study examined crown motifs, N-glycosylation sites, and T8V mutations in all subtypes. R5 viruses are common in subtypes A, B, C, and CRF35-AD. These data indicate that R5 viruses in subtypes A and B are more prone to crown motif formation. The first report assessed the tropism of common HIV-1 subtypes and reported that CCR5 inhibitors could help treat patients with all subtypes but not AE. WebPSSM is a suitable method for determining HIV-1 tropism in different subtypes. Finally, large cohorts to assess virological response to CCR5 inhibitors would provide deep insight into the practicality of genotypic methods in clinical settings.
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