ArticleFrontiers in ophthalmology2025
Case report: Two cases of multiple evanescent white dot syndrome with transient night blindness.
Article in Frontiers in ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Non-Infectious Choroiditis Subdivided into Its Diverse Pathophysiological Sub-Groups Is the Best-Known and Most Appropriate Nomenclature to Date for the Reclassification and Diagnosis of Former White Dot Entities.Diagnostics (Basel, Switzerland) · 2026Review
- Opposing pathophysiological concepts in multiple evanescent white dot syndrome: The great MEWDS schism.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyReview
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This study aimed to report two cases of multiple evanescent white dot syndrome (MEWDS) with transient night blindness. Case Presentation: Case 1: A 24-year-old man presented with acute visual loss and night blindness in his right eye. Examination revealed an enlarged blind spot and multiple white dots extending from the posterior pole to the peripheral retina in the right eye. Optical coherence tomography (OCT) revealed multiple disruptions of the ellipsoid zone (EZ). Full-field electroretinography (ffERG) demonstrated a more pronounced reduction in rod amplitude compared with cone amplitude in both eyes. After 3 months, the white dots, EZ disruption, and night blindness resolved spontaneously, and the ffERG amplitude normalized in the right eye. However, the enlarged blind spot persisted. Case 2: A 66-year-old woman presented with acute visual deterioration and night blindness in her right eye. The right eye exhibited an enlarged blind spot and numerous white spots widely extending from the posterior pole to the periphery. OCT revealed widespread EZ loss, and ffERG showed reduced rod and cone responses. SubTenon's triamcinolone acetonide injection was administered, and 3 months after the injection, the night blindness, ffERG abnormalities, and EZ loss had resolved, but the enlarged blind spot remained. Conclusion: MEWDS rarely causes transient night blindness due to extensive rod dysfunction. However, outer retinal layer damage is reversible, with night blindness typically resolving within a few months.
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