ArticleEuropean journal of neurology2025
Precipitating Factors for Functional Cognitive Disorder.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Positive Clinical Signs of Functional Neurological Disorders Are Found in Patients With Functional Cognitive Disorders.Brain and behavior · 2026Article
- Cognitive Trajectories After Hospitalization for COVID-19: A 36-Month Longitudinal Study.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- The Medicolegal Implications of Functional Neurological Disorder.Seminars in neurology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundThe underlying mechanisms of functional cognitive disorder (FCD) are still poorly understood. This hinders diagnostic identification and establishment of personalised and effective treatments. We aimed to describe the precipitating factors for new-onset FCD and explore differences between the acute and gradual onset FCD groups.
methodsRetrospective analysis of a consecutive sample of FCD patients seen in three dedicated clinics in the United Kingdom between September 2023 and March 2024. Only patients with at least one-year symptom duration were included. We extracted mode of onset and precipitating factors, demographics, comorbidities, family history of cognitive symptoms, personal exposure to dementia, symptom duration and trajectory, as well as cognitive testing when available.
resultsNinety-three patients were included, of which 45 had an acute onset of functional cognitive symptoms (48% of total). Of the acute onset group, 51% were female; mean age of symptom onset was 44 years (± 12). In the acute onset group, COVID-19 (n = 18, 40%), head injury (n = 16, 36%) and migraine (n = 16, 36%) were the most common precipitating factors for symptom onset, followed by cardiovascular/vasovagal events, dissociative episodes, panic, medication change, medical procedure under sedation and acute vertigo. The acute onset group was younger, most commonly had a fluctuating course of symptoms, and more headache and fatigue than the gradual onset group.
conclusionsFunctional cognitive disorder often begins acutely. The circumstances around onset may have treatment and prognostic implications. Similar to other functional disorders, the experience of abnormal cognition from an acute pathophysiological event can act as powerful precipitating factors for functional cognitive disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.