Evidence map›Paper›PMID 40034034›Full record

ArticleProteins2025

Investigating Local Sequence-Structural Attributes of Amyloidogenic Light Chain Variable Domains.

Puneet Rawat, R Prabakaran, Divya Sharma, Vasanth Mandala, Victor Greiff, Sandeep Kumar, M Michael Gromiha

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Puneet RawatUniversity of Oslo and Oslo University Hospital, Oslo, Norway.ORCID 0000-0002-3822-8081
R PrabakaranProtein Bioinformatics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.ORCID 0000-0002-0172-3716
Divya SharmaProtein Bioinformatics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.
Vasanth MandalaBiotherapeutics Discovery, Boehringer-Ingelheim Inc, Ridgefield, Connecticut, USA.
Victor GreiffUniversity of Oslo and Oslo University Hospital, Oslo, Norway.
Sandeep KumarBiotherapeutics Discovery, Boehringer-Ingelheim Inc, Ridgefield, Connecticut, USA.ORCID 0000-0003-2840-6398
M Michael GromihaProtein Bioinformatics Lab, Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai, India.ORCID 0000-0002-1776-4096

Funding

EU Horizon 2020European Research CouncilKreftforeningenLeona M. and Harry B. Helmsley Charitable TrustMarie Skłodowska-CurieNorges ForskningsrådUiO: LifeScience Convergence EnvironmentUiO World-Leading Research Community
6 · The paper itself

Abstract

Light chain amyloidosis is a medical condition characterized by the aggregation of misfolded antibody light chains into insoluble amyloid fibrils in the target organs, causing organ dysfunction, organ failure, and death. Despite extensive research to understand the factors contributing to amyloidogenesis, accurately predicting whether a given protein will form amyloids under specific conditions remains a formidable challenge. In this study, we have conducted a comprehensive analysis to understand the amyloidogenic tendencies within a dataset containing 1828 (348 amyloidogenic and 1480 non-amyloidogenic) antibody light chain variable region (V

Indexed as

AmyloidAmyloidogenic ProteinsImmunoglobulin Light ChainsImmunoglobulin Variable RegionAmino Acid SequenceDatabases, ProteinHumansHydrophobic and Hydrophilic InteractionsImmunoglobulin Light-chain AmyloidosisProtein AggregatesProtein DomainsAmyloidAmyloidogenic ProteinsImmunoglobulin Light ChainsImmunoglobulin Variable RegionProtein Aggregatesaggregation‐prone regionsAL amyloidosisamyloidantibody aggregationantibody structurelight chain amyloidosisstructural gatekeepers

Identifiers

PMID40034034
PMCPMC12314586

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.