Evidence map›Paper›PMID 40033993›Full record

ArticleJournal of neuromuscular diseases2025

Cardiopulmonary exercise testing as an integrative approach to explore physiological limitations in Duchenne muscular dystrophy.

Meghana Bomma, Donovan Lott, Sean Forbes, Renata Shih, John-Anthony Coppola, Jeffrey W Christle, Tina Duong, Joseph Russo, Aditi Pant, Carmen Leon-Astudillo and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuromuscular diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Meghana BommaDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Donovan LottDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Sean ForbesDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
Renata ShihDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
John-Anthony CoppolaDepartment of Pediatrics, Congenital Heart Center, University of Florida, Gainesville, FL, USA.
Jeffrey W ChristleDivision of Cardiovascular Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
Tina DuongDivision of Neurology and Neurological Sciences, Department of Medicine, Stanford University, Stanford, CA, USA.
Joseph RussoDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.ORCID 0009-0009-7129-5807
Aditi PantDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
Carmen Leon-AstudilloDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
Julie BerthyDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
Christina CousinsDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
Manuela CortiDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
Barry ByrneDepartment of Pediatrics, University of Florida, Gainesville, FL, USA.
James MayDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.
W XueDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Tanja TaivassaloDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8923-2921

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiopulmonary exercise testing (CPET) is the gold-standard for quantification of peak oxygen uptake (VO

objectiveTo investigate the utility of CPET in DMD by 1) establishing whether patients can perform maximal-effort exercise for valid VO

methodsTwenty-seven DMD and eight healthy boys (6 years and older) underwent CPET using an incremental work-rate protocol for leg (ambulatory) or arm (non-ambulatory) cycling with measurement of heart rate (HR) and gas-exchange variables from rest to maximal-effort. The oxygen cost of work (ΔVO

resultsVO

conclusionValid CPET is feasible in DMD, revealing low VO

Indexed as

Exercise TestMuscular Dystrophy, DuchenneOxygen ConsumptionAdolescentChildHeart RateHumansMaleReproducibility of ResultsWalk Testaerobic capacitycardiorespiratoryexercise capacityleg and arm cycle exercisenon-invasive outcomespeak heart rateSecondary: Duchenne muscular dystrophyventilatory inefficiencyventilatory threshold

Identifiers

PMID40033993
PMCPMC13142889

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.