Evidence map›Paper›PMID 40033956›Full record

ArticleAnnals of rehabilitation medicine2025

Early Rehabilitation Interventions by Physical Therapists for Severe COVID-19 Patients Were Associated With Decreased Incidence of Post-ICU Physical Impairment.

Shinya Oku, Junji Hatakeyama, Keibun Liu, Kentaro Tojo, Masafumi Idei, Shigeaki Inoue, Kazuma Yamakawa, Takeshi Nishida, Shinichiro Ohshimo, Satoru Hashimoto and 28 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of rehabilitation medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors.

Shinya OkuDepartment of Anesthesiology, Yokohama City University Hospital, Yokohama, Japan.
Junji HatakeyamaDepartment of Emergency and Critical Care Medicine, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
Keibun LiuCritical Care Research Group, The Prince Charles Hospital, Brisbane, QLD, Australia.
Kentaro TojoDepartment of Critical Care Medicine, Yokohama City University Hospital, Yokohama, Japan.
Masafumi IdeiDepartment of Critical Care Medicine, Yokohama City University Hospital, Yokohama, Japan.
Shigeaki InoueDepartment of Disaster and Emergency Medicine, School of Medicine, Kobe University, Kobe, Japan.
Kazuma YamakawaDepartment of Emergency and Critical Care Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Takeshi NishidaDivision of Trauma and Surgical Critical Care, Osaka General Medical Center, Osaka, Japan.
Shinichiro OhshimoDepartment of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Satoru HashimotoNon-Profit Organization ICU Collaboration Network (ICON), Tokyo, Japan.
Shuhei MaruyamaDepartment of Emergency and Critical Care Medicine, Kansai Medical University Medical Center, Osaka, Japan.
Yoshitaka OgataDepartment of Critical Care Medicine, Yao Tokushukai General Hospital, Osaka, Japan.
Daisuke KawakamiDepartment of Anesthesia and Critical Care, Kobe City Medical Center General Hospital, Kobe, Japan.
Hiroaki ShimizuAcute Care Medical Center, Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan.
Katsura HayakawaDepartment of Emergency and Critical Care Medicine, Saitama Red Cross Hospital, Saitama, Japan.
Yuji FujinoDepartment of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Taku OshimaDepartment of Emergency and Critical Care Medicine, Chiba University Graduate School of Medicine, Chiba, Japan.
Tatsuya FuchigamiIntensive Care Unit, University of the Ryukyus Hospital, Okinawa, Japan.
Hironori YawataDepartment of Emergency and Critical Care Medicine, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan.
Kyoji OeDepartment of Intensive Care Medicine, Asahi General Hospital, Chiba, Japan.
Akira KawauchiJapanese Red Cross Maebashi Hospital, Advanced Medical Emergency Department and Critical Care Center, Maebashi, Japan.
Hidehiro YamagataAdvanced Critical Care and Emergency Center, Yokohama City University Medical Center, Yokohama, Japan.
Masahiro HaradaDepartment of Emergency and Critical Care, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan.
Yuichi SatoCritical Care and Emergency Center, Metropolitan Tama General Medical Center, Tokyo, Japan.
Tomoyuki NakamuraDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Nagoya, Japan.
Kei SugikiDepartment of Intensive Care Medicine, Yokohama City Minato Red Cross Hospital, Yokohama, Japan.
Takahiro HakozakiDepartment of Anesthesiology, Fukushima Medical University, Fukushima, Japan.
Satoru BeppuDepartment of Emergency and Critical Care Medicine, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Masaki AnrakuDepartment of Thoracic Surgery, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Tokyo, Japan.
Noboru KatoDepartment of Emergency and Critical Care Medicine, Yodogawa Christian Hospital, Osaka, Japan.
Tomomi IwashitaDepartment of Emergency and Critical Care Center, Nagano Red Cross Hospital, Nagano, Japan.
Hiroshi KamijoDepartment of Emergency and Critical Care Medicine, Shinshu University Hospital, Nagano, Japan.
Yuichiro KitagawaEmergency and Disaster Medicine, Gifu University School of Medicine Graduate School of Medicine, Gifu, Japan.
Michio NagashimaDepartment of Intensive Care Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Hirona NishimakiDepartment of Anesthesiology, Tohoku University Hospital, Sendai, Japan.
Kentaro TokudaIntensive Care Unit, Kyushu University Hospital, Fukuoka, Japan.
Osamu NishidaDepartment of Anesthesiology and Critical Care Medicine, Fujita Health University School of Medicine, Nagoya, Japan.
Kensuke NakamuraDepartment of Critical Care Medicine, Yokohama City University Hospital, Yokohama, Japan.

Funding

Nestlé Health Science Company of Nestlé Japan
6 · The paper itself

Abstract

objectiveTo implement early rehabilitation interventions by physical therapists is recommended. However, the effectiveness of early rehabilitation for severe coronavirus disease 2019 (COVID-19) patients in the prevention of post-intensive care syndrome (PICS) is unclear. We analyzed a multicenter prospective observational study (Post-Intensive Care outcomeS in patients with COronaVIrus Disease 2019) to examine the association between early rehabilitation interventions and PICS physical impairment.

methodsAn analysis was performed on COVID-19 patients who were admitted to intensive care units (ICUs) between March 2020 and March 2021, and required mechanical ventilation. The primary outcome was the incidence of PICS physical impairment (Barthel Index≤90) after one year. Multivariate logistic regression analysis was used to estimate the association between early rehabilitation interventions and PICS physical impairment by adjusting ICU mobility scale (IMS) during seven-day following ICU admission, and clinically relevant risk factors.

resultsThe analysis included 259 patients, 54 of whom developed PICS physical impairment one year later. In 81 patients, physical therapists intervened within seven days of ICU admission. There was no significant difference in mean IMS by day seven of admission between the early and non-early rehabilitation patients (0.70 and 0.61, respectively). Multivariate logistic regression analysis showed that early rehabilitation interventions were significantly associated with a low incidence of PICS physical impairment (odds ratio, 0.294; 95% confidence interval, 0.123-0.706; p=0.006).

conclusionEarly rehabilitation interventions by physical therapists were an independent factor associated with the decreased development of PICS physical impairment at one year, even though early rehabilitation had no significant effect on IMS.

Indexed as

COVID-19Critical illnessPost-intensive care syndromeRehabilitation

Identifiers

PMID40033956
PMCPMC11895053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.