Evidence map›Paper›PMID 40033939›Full record

ArticleScience progress

Single versus dual antiplatelet therapy impact on coagulation/thrombosis post PAD revascularization.

Adriana A Rodriguez Alvarez, Shiv S Patel, Isabella F Cieri, Samir Ghandour, Mounika Boya, Sasha P Suarez, Aniket Agrawal, Ivy Lee, Lois Owolabi, Mohit Manchella and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Adriana A Rodriguez AlvarezDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5394-3323
Shiv S PatelDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Isabella F CieriDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Samir GhandourDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Mounika BoyaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Sasha P SuarezDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0965-7258
Aniket AgrawalDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Ivy LeeDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Lois OwolabiDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Mohit ManchellaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Anahita DuaDivision of Vascular and Endovascular Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3349-4233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate and compare the impact of single- versus dual-antiplatelet (SAPT vs DAPT) therapy on coagulation profiles and postoperative outcomes in patients with peripheral arterial disease (PAD).

methodsPatients with PAD undergoing lower extremity revascularization from December 2020 to August 2023 were prospectively enrolled in this cohort study and followed for one year to record the incidence of thrombotic events (TEs). These events include arterial graft/stent occlusion or stenosis, as identified through Doppler ultrasonography or angiography. Patients were categorized by type of intervention (open vs. endovascular) and further stratified by thromboprophylaxis regimen (SAPT vs DAPT). Descriptive statistics were conducted to characterize each group. Differences in continuous variables were analyzed using Student's t-test, while categorical variables were evaluated using Fisher's exact test. Kaplan-Meier survival curves and cox proportional hazard assessed the thrombosis probability between groups.

resultsA total of 157 patients were analyzed, of which 56 were open and 101 were endovascular. In the endovascular group, the majority of patients were on DAPT (61.4%), whereas in the open procedure, most individuals were on SAPT (78.6%). DAPT recipients exhibited a lower prothrombotic profile than SAPT recipients in either operative cohort (

conclusionWhile DAPT demonstrated lower prothrombotic thromboelastography with platelet mapping profiles compared to SAPT, this did not translate into differences in index TEs across surgical modalities.

Indexed as

Blood CoagulationDual Anti-Platelet TherapyPeripheral Arterial DiseasePlatelet Aggregation InhibitorsThrombosisAgedEndovascular ProceduresFemaleHumansMaleMiddle AgedProspective StudiesTreatment OutcomePlatelet Aggregation Inhibitorsarterial diseaselower extremityperipheral vascular diseasePlatelet aggregation inhibitorsthrombosis

Identifiers

PMID40033939
PMCPMC11877524

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.