Evidence map›Paper›PMID 40033852›Full record

ArticleAngewandte Chemie (International ed. in English)2025

In-Cell Fast Photochemical Oxidation Interrogates the Native Structure of Integral Membrane Proteins.

Jie Sun, Mierxiati Saimi, Don Rempel, Qing Cao, Mengqi Chai, Weikai Li, Michael L Gross

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Single-Injection Multi-Omics Analysis by Direct Infusion Mass Spectrometry.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. State-of-the-Art and Future Directions in Structural Proteomics.Molecular & cellular proteomics : MCP · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jie SunDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, Box 1134, St. Louis, MO, 63130, USA.
Mierxiati SaimiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Ave, Box 8231, St. Louis, MO, 63110, USA.
Don RempelDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, Box 1134, St. Louis, MO, 63130, USA.
Qing CaoDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Ave, Box 8231, St. Louis, MO, 63110, USA.
Mengqi ChaiDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, Box 1134, St. Louis, MO, 63130, USA.
Weikai LiDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, 660 S. Euclid Ave, Box 8231, St. Louis, MO, 63110, USA.
Michael L GrossDepartment of Chemistry, Washington University in St. Louis, One Brookings Drive, Box 1134, St. Louis, MO, 63130, USA.

Funding

NEW CHEMICAL PROBES ENABLE MASS SPECTROMETRY-BASED FOOTPRINTING OF HUMAN PROTEIN STRUCTURE IN LIPID MEMBRANES AND CELLSR01GM131008 · NIGMS · WASHINGTON UNIVERSITY · PI MICHAEL L GROSS, Weikai Li · 2019 to 2026
$3.8M
A Biomedical Mass Spectrometry Resource: Ongoing Driving Biomedical ProjectsR24GM136766 · NIGMS · WASHINGTON UNIVERSITY · PI GROSS, MICHAEL L · 2020 to 2022
$2.3M
NIGMS NIH HHS R01 GM131008NIGMS NIH HHS R24 GM136766NIH HHS 5R01GM13100802
6 · The paper itself

Abstract

Integral membrane proteins (IMPs) are pivotal for cellular functions but challenging to investigate. Here, IC-FPOMP (in-cell fast photochemical oxidation of MPs) is introduced, a method enabling in situ footprinting of IMPs within live cells. IC-FPOMP generates reactive oxygen radicals from various precursors (TiO

Indexed as

Glucose Transporter Type 1Membrane ProteinsHumansHydrogen PeroxideOxidation-ReductionPhotochemical ProcessesTitaniumGlucose Transporter Type 1Hydrogen PeroxideMembrane ProteinsSLC2A1 protein, humanTitaniumAnalytical chemistryDrug discoveryFast photochemical oxidation of proteins (FPOP)Human transmembrane proteinsIn‐cell Protein footprintingNanoparticles

Identifiers

PMID40033852
PMCPMC12052488

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.