Evidence map›Paper›PMID 40033808›Full record

ArticleJournal of applied biomedicine2024

Association between mean platelet volume and adiponectin in patients with metabolic syndrome.

Milos Marinkovic, Jelena Nesic, Ivica Petrovic, Ivan P Jovanovic, Marija Sekulic, Svetlana Djukic, Aleksandar Djukic

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Article in Journal of applied biomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Milos MarinkovicUniversity Clinical Center Kragujevac, Serbia.
Jelena NesicUniversity Clinical Center Kragujevac, Serbia.
Ivica PetrovicUniversity of Kragujevac, Faculty of Medical Sciences, Department of Pathophysiology, Kragujevac, Serbia.
Ivan P JovanovicUniversity of Kragujevac, Faculty of Medical Sciences, Centre for Molecular Medicine and Stem Cell Research, Kragujevac, Serbia.
Marija SekulicUniversity of Kragujevac, Faculty of Medical Sciences, Department of Hygiene and Ecology, Kragujevac, Serbia.
Svetlana DjukicUniversity Clinical Center Kragujevac, Serbia.
Aleksandar DjukicUniversity Clinical Center Kragujevac, Serbia.

Funding

Faculty of Medical Sciences, the University of Kragujevac JP 01/23
6 · The paper itself

Abstract

backgroundMetabolic syndrome is a significant pro-inflammatory and pro-coagulant condition. The clinical association of adiponectin, a mainly antidiabetogenic molecule, and its interaction with platelets and platelet indices remains insufficiently investigated.

objectiveThe aim of our study was to investigate the association of adiponectin with platelets and platelet indices in patients with metabolic syndrome.

methodsThe investigation was conducted as a cross-sectional study involving 113 subjects: 63 patients with the diagnosis of metabolic syndrome, and 50 healthy controls - with clear inclusion and exclusion criteria. The group of patients with metabolic syndrome was divided into two subgroups according to the platelet/high-density lipoprotein (HDL) ratio.

resultsThe subgroup with a higher platelet/HDL ratio was prediabetic. In the same subgroup of patients, a positive correlation between the adiponectin and mean platelet volume (MPV) was seen, while linear regression (95% CI) confirmed the association.

conclusionConsidering that MPV is the index that indicates average platelet volume and activity, we believe this association with adiponectin can represent a protective compensatory response in patients with metabolic syndrome and prediabetes. Our results provide a basis for a more precise selection of patients in whom the future therapeutic application of recombinant adiponectin would be most effective.

Indexed as

AdiponectinBlood PlateletsMean Platelet VolumeMetabolic SyndromeAdultCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedAdiponectinAdiponectinMean platelet volumeMetabolic syndromePlatelets

Identifiers

PMID40033808

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