ArticleJournal of Alzheimer's disease : JAD2025
Measures of retinal health successfully capture risk for Alzheimer's disease and related dementias at midlife.
Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- An Ensemble Learning Artificial Intelligence Model for Alzheimer's Disease Detection Using OCT.Ophthalmology science · 2026Article
- Disease Diagnosis Using Retinal Vasculature: Insights from Flammer Syndrome and AI.Brain sciences · 2025Review
- A Window to the Brain-The Enduring Impact of Vision Research.Brain sciences · 2025Review
- Applications and implicit assumptions in dementia risk scores: A scoping review of the LIBRA score.Journal of Alzheimer's disease reportsReview
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Authors and funding
12 authors.
Funding
Abstract
BackgroundIdentification of at-risk individuals who would benefit from early intervention for Alzheimer's disease and related dementias (ADRD) is critical as new treatments are developed. Measures of retinal health could offer accessible and low-cost indication of pre-morbid disease risk, but their association with ADRD risk is unknown.ObjectiveTo determine whether midlife retinal neuronal and microvascular measures are associated with ADRD risk-index scores and individual domains of ADRD risk.MethodsData were from the Dunedin Multidisciplinary Health and Development Study, a population-representative longitudinal New Zealand-based birth cohort study. 94.1% (N = 938) of living Study members were seen at age 45 (2017-2019). Retinal neuronal (retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GC-IPL)) and microvascular (arterioles and venules) measures were used as predictors. Outcome measures were four top ADRD risk indexes (CAIDE, LIBRA, Lancet, and ADU-ADRI), and a comprehensive midlife ADRD risk index, the DunedinARB.ResultsPoorer retinal microvascular health (narrower arterioles and wider venules) was associated with greater ADRD risk (βs = 0.16-0.31;
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