ArticleMedical science monitor : international medical journal of experimental and clinical research2025
Gastrointestinal System Endoscopy and Pathological Findings in Non-Dialysis Chronic Kidney Disease: A Single-Center Study.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Chronic kidney disease as an active driver of digestive tract tumors: mechanistic insights and emerging management strategies.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Different gastrointestinal complications can occur due to moderate and severe kidney function loss in chronic kidney disease (CKD). This study examined the endoscopic and pathological findings in CKD patients with renal failure who were not receiving dialysis treatment and renal transplantation. MATERIAL AND METHODS A total of 60 pre-dialysis CKD patients who underwent upper-gastrointestinal endoscopy due to dyspeptic concerns were included. Endoscopic and pathological findings were compared with those of 68 non-uremic patients with similar concerns. Dyspeptic symptoms included upper-abdominal discomfort, nausea, vomiting, anorexia, indigestion, and regurgitation. Serum creatinine levels ≥1.5 mg/dL and eGFR stages 3a-4 (KDIGO guidelines) were used to define CKD. RESULTS This study found no significant difference in gastroesophageal reflux frequency between the groups. However, antral gastritis, erythematous gastritis, active chronic gastritis, and non-ulcerative lesions were significantly more frequent in CKD patients (P<0.001). Conversely, erosive pangastritis was more prevalent in the non-CKD group. Helicobacter pylori (HP) frequency was significantly lower in CKD patients (23.5%) compared to the non-CKD group (59.1%, P<0.001). Intestinal metaplasia, atrophy, and metaplastic gastritis rates were similar in both groups. Multivariate analysis identified gastritis and serum calcium as independent factors affecting HP positivity. CONCLUSIONS In CKD patients, uremic toxins, impaired circulation, and hypergastrinemia likely contribute to mucosal damage and increased the risk of gastrointestinal complications. Early detection and management of these lesions in pre-dialysis CKD patients are crucial, especially for kidney transplant candidates. Endoscopic evaluation and appropriate treatment can help reduce potential complications associated with immunosuppressive therapy and can improve patient outcomes.
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