ArticleJournal of hepato-biliary-pancreatic sciences2025
Mortality and cardiovascular disease after cholecystectomy in type 2 diabetes: A nationwide longitudinal cohort study.
Article in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Incidence and Predictors of Perioperative Cardiac Events in Emergency Abdominal Surgeries: A Retrospective Study.Cureus · 2026Article
- Postoperative Blood Glucose Spikes Predict Morbidity After Pancreatoduodenectomy.Journal of diabetes research · 2026Observational
- Mortality and cardiovascular disease after cholecystectomy in type 2 diabetes: A nationwide longitudinal cohort study.Journal of hepato-biliary-pancreatic sciences · 2025Article
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Authors and funding
7 authors.
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Abstract
backgroundThe long-term effects of cholecystectomy on mortality and cardiovascular disease (CVD) in patients with diabetes have not been evaluated. In the present study, we investigated the longitudinal effects of cholecystectomy on mortality and CVD in a population-based cohort with type 2 diabetes (T2D).
methodsIn total, 2 216 930 national health examination participants with T2D, including 19 258 patients with cholecystectomy, were followed up for a median of 7.9 years. The adjusted hazard ratios (aHRs) were calculated for all-cause mortality and CVD (myocardial infarction or ischemic stroke) in the cholecystectomy group compared with the nonoperative controls.
resultsThe cholecystectomy group had a significantly higher risk of mortality than controls (aHR 1.10, 95% confidence interval [CI]: 1.06-1.14), which was more pronounced in younger participants (aHR 1.67 [1.38-2.03], 1.22 [1.13-1.31], and 1.05 [1.00-1.10] for those aged <50, 50-64, and ≥65 years) and participants with less advanced diabetes treatment. The risk of CVD was increased with cholecystectomy only in those aged <50 years (aHR 1.24 [1.01-1.52]).
conclusionsCholecystectomy in patients with T2D is associated with an increased risk of all-cause mortality, particularly in younger patients without diabetes medication. Only patients aged <50 years have a higher risk of developing CVD after cholecystectomy.
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