Evidence map›Paper›PMID 40033602›Full record

ReviewCurrent medicinal chemistry2026

The Role of Lipid Rafts in the Mitogen-Activated Protein Kinase Signaling in Cancer.

Khadijeh Abbasi, Bahar Zarei, Halimeh Amirazad, Tannaz Novinbahador, Aysan Seyyedi, Yosra Vaez-Gharamaleki, Amir Mehdizadeh, Reza Zarezadeh

Abstract readReview
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In one paragraph

Review in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khadijeh AbbasiStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Bahar ZareiDepartment of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
Halimeh AmirazadEndocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tannaz NovinbahadorDepartment of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Aysan SeyyediDepartment of Biology, University College of Nabi Akram, Tabriz, Iran.
Yosra Vaez-GharamalekiHematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Amir MehdizadehHematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Reza ZarezadehWomen's Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Funding

Hematology and Oncology Research Center at Tabriz University of Medical Sciences 67803
6 · The paper itself

Abstract

Specific regions of plasma membrane enriched with cholesterol and sphingolipids, recognized as lipid rafts or membrane rafts, play an essential part in cell signal transduction. The ability to actively utilize or exempt signaling proteins for the reinforcement or inactivation of specific signaling pathways is the prominent characteristic of lipid rafts, enabling them to act as lipid-based units that can affect signal transduction and cell activity. A connection between lipid raft structure changes and enhancement of the mitogen-activated protein kinase (MAPK) pathway has been reported. Moreover, alteration in lipid raft construction in cancer has also been confirmed. Thus, this review aimed to study the relationship between lipid rafts and the MAPK signaling pathway in a variety of cancer types.

Indexed as

MAP Kinase Signaling SystemMembrane MicrodomainsMitogen-Activated Protein KinasesNeoplasmsAnimalsHumansSignal TransductionMitogen-Activated Protein Kinaseschemoresistance.ERK1/2Lipid raftsMAPKsignal transductiontumor

Identifiers

PMID40033602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.