SynthesisParasite immunology2025
How Effective Are the Canine Visceral Leishmaniasis Vaccines Currently Being Tested in Dogs? A Systematic Review and Meta-Analysis.
Synthesis in Parasite immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Sustainable Antiparasitic Agents from an Agro-Industrial Waste: Mitochondria-Targeting Cashew Nutshell Liquid-Derived Phosphonium and Ammonium Salts.Journal of medicinal chemistry · 2025Article
- Overview of Commercial Vaccines Against Canine Visceral Leishmaniasis: Current Landscape and Future Directions.Pathogens (Basel, Switzerland) · 2025Review
- Emergence of autochthonousFrontiers in veterinary science · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Canine visceral leishmaniasis (CVL) is a zoonotic disease of great worldwide importance and can be prevented by vaccinating seronegative dogs. The objective of the present systematic review and meta-analysis is to verify the efficacy rate of vaccines tested in dogs against CVL or L. infantum infection. We used PRISMA guidelines for this review and Pubmed, Web of Science, Scopus, Cochrane, Scielo and CABI to find studies about vaccines against CVL in dogs. Articles were analysed and grouped according to the antigens used. The risk of bias analysis was performed using SYRCLE's RoB tool and meta-analysis using R Statistical language. The final analysis was conducted using 22 studies that assessed DNA, excreted/secreted proteins and subunit vaccines, involving a total of 92 animals, 96 animals and 78 animals, respectively. Regarding DNA vaccines, the analyses revealed non-significant results in terms of preventing parasite presence in the organs or the onset of clinical signs. However, subunit vaccines demonstrated statistically significant results concerning parasite presence in the organs, but not when it comes to clinical signs. Additionally, there was no statistically significant difference observed in parasite burden in the organs or clinical signs for the excreted/secreted vaccines. The meta-analysis indicated that subunit and excreted/secreted protein vaccines were significantly more effective in preventing parasites in vaccinated animals compared to both DNA-based vaccines and control groups. Heterogeneity among studies is a limitation, emphasising the need for standardised protocols for reliable comparisons.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.