Evidence map›Paper›PMID 40033511›Full record

ArticleCurrent neuropharmacology2025

Peripheral Inflammation Profile of Cerebellar Ataxia.

Cuiling Tang, Qi Deng, Xinrong Yuan, Ziyan Ding, Jian Hu, Linliu Peng, Hongyu Yuan, Na Wan, Yiqing Gong, Siyu Ding and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current neuropharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Evaluating the causal effects of circulating metabolites on major depression disorder.European archives of psychiatry and clinical neuroscience · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cuiling TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Qi DengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Xinrong YuanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Ziyan DingDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jian HuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Linliu PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Hongyu YuanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Na WanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yiqing GongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Siyu DingDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yan TanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Lijing LeiDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Linlin WanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Rong QiuSchool of Computer Science and Engineering, Central South University, Changsha, 410083, China.
Beisha TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.

Funding

Central South University Research Programme of Advanced Interdisciplinary Study 2023QYJC010Furong Lab Research Project 2023SK2084Major Scientific Research Project for High-level Health Talent in Hunan Province R2023047National Key R&D Program of China 2021YFA0805200National Natural Science Foundation of China 82171254, 82371272, 82301438, 82201411, 82401496Natural Science Foundation of Hunan Province 2024JJ3050Postdoctoral Fellowship Program of CPSF GZB20230870Science and Technology Innovation Program of Hunan Province 2022RC1027
6 · The paper itself

Abstract

objectivesThe objective of this study is to determine the characteristics of peripheral inflammatory profiles and their correlations with the clinical features in patients with cerebellar ataxia.

methodsWe conducted a cross-sectional study on a cohort of 140 cerebellar ataxia patients, including 74 patients with spinocerebellar ataxia (SCA), 66 patients with multiple system atrophy with predominant cerebellar ataxia (MSA-C), and 145 healthy controls (HCs). Inflammatory profiles (PLT, MPV, NLR, PLR, MLR, SII, AISI and ESR) were measured in peripheral blood, and were compared by ANOVA and Kruskal-Wallis test. The receiver operating characteristic (ROC) curve and the area under curve (AUC) were performed to determine the sensitivity and specificity of the inflammatory markers. Spearman correlation and partial correlation analysis were performed to detect the association between inflammatory profiles and clinical scales in cerebellar ataxia.

resultsInflammatory profiles from peripheral blood showed significant difference between different groups. Significant variations were observed in MPV, NLR, MLR, SII, AISI and ESR between cerebellar ataxia and HCs groups (p<0.05). NLR and ESR in both SCA and MSA-C groups were increased compared with HCs (p<0.05). The difference of MHR between SCA and MSA-C groups was observed based on HDL variation (p<0.05). The combination of ESR and PLT distinguished SCA from MSA-C (AUC=0.800). In addition, MLR was significantly corelated with clinical scales, including SARA and ICARS in SCA group as well as UMSARS and FAB in MSA-C group (r>0.3/r<-0.3).

conclusionSignificant variation in peripheral inflammatory profiles was firstly identified in Chinese genetic ataxias and non-genetic cerebellar ataxia cohort, which showed the potential clinical correlations between peripheral inflammatory phenotype and severity of ataxia.

Indexed as

Cerebellar AtaxiaInflammationMultiple System AtrophyAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansMaleMiddle AgedSpinocerebellar AtaxiasBiomarkersbiomarkersblood routine examinationCerebellar ataxiaperipheral inflammationreceiver operating characteristic (ROC)RNA.

Identifiers

PMID40033511
PMCPMC12307985

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.