Evidence map›Paper›PMID 40033505›Full record

ArticleCurrent stem cell research & therapy2025

HuMenSCs Initiate the Uterus Stromal Decidualization in Mouse.

Yibing Han, Zhaoyi Li, Hongliu Shi, Yang Dong, Tai Ip Chan, Gang Xiao, Yi Zhun Zhu

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Article in Current stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yibing HanPathology, Kiang Wu Hospital, Macau, China.
Zhaoyi LiDepartment of Pharmacology, School of Medicine and Pharmacology, Macau University of Sciences and Technology, Macau, China.
Hongliu ShiFuyuan Bio-life Co, LTD. Guangzhou, China.
Yang DongDepartment of Obstetrics and Gynaecology, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong S.A.R., China.
Tai Ip ChanPathology, Kiang Wu Hospital, Macau, China.
Gang XiaoPathology, Kiang Wu Hospital, Macau, China.
Yi Zhun ZhuDepartment of Pharmacology, School of Medicine and Pharmacology, Macau University of Sciences and Technology, Macau, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionHuman menstrual blood stem cells (huMenSCs) appear to be pre-clinically safe but a controlled phase I clinical trial is required to determine safety for clinical applications.

methodsHuMenSCs established from healthy donors were free of bacteria, mycoplasma, chlamydia, and endotoxin. P3 (passage 3) huMenSCs expressed the mesenchymal stem cell markers. P6 huMenSCs were developmental multipotential and could translocated into the uterine subepithelial stroma after intrauterine transplantation. After 10 and 15 passages, the huMenSCs kept normal karyotypes.

resultsGene expression showed that compared with the human umbilical cords mesenchymal stem cells (huMSCs), the huMenSCs affected the stromal cells more effectively. The huMenSCs possibly enhanced the stromal cell multiplication and "decidualization" process initiated by Igfbp1.

conclusionExpression of

Indexed as

DeciduaMenstruationMesenchymal Stem CellsStromal CellsUterusActivating Transcription Factor 3AnimalsCell DifferentiationCells, CulturedCyclooxygenase 2FemaleForkhead Transcription FactorsHomeobox A10 ProteinsHomeodomain ProteinsHumansInsulin-Like Growth Factor Binding Protein 1Activating Transcription Factor 3Cyclooxygenase 2Forkhead Transcription FactorsHomeobox A10 ProteinsHomeodomain ProteinsInsulin-Like Growth Factor Binding Protein 1Nuclear Receptor Subfamily 4, Group A, Member 1biosafety testdecidualization.huMenSCshuMSCsintrauterine transplantationstromal cells

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.