ArticleColorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland2025
High-grade intraepithelial lesions of the anus-patience: A road to wisdom.
Article in Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- High-grade intraepithelial lesions of the anus-patience: A road to wisdom.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe progression of high-grade squamous intraepithelial lesions (HSILs) to anal cancer is feared. Data on the remission of HSILs are scarce, and factors associated with remission have not been identified. The aims of this study were to determine the rate of remission of HSILs and to identify factors associated with remission.
methodConsecutive patients with HSILs referred to a tertiary proctology unit for monitoring were identified in a prospective database. Clinical data, as well as cytological, histological and treatment data, were recorded. The remission of HSILs was defined by the normality of the macroscopic examination and the normal histology and/or cytology of at least two consecutive samples.
resultsOverall, 144 patients with HSILs were followed for 4.1 (2.1-6.5) years. The cumulative probabilities of remission of HSILs were 9.7% (6.2%-14.9%), 14.6% (10.1%-20.7%) and 23.8% (17.3%-31.8%) at 2, 3 and 5 years, respectively. Human papillomavirus 16 (HPV16) clearance was achieved in 19/84 (22.6%) patients. Multivariate analysis revealed that three main factors were associated with remission of HSILs: absence of HPV16 at referral [hazard ratio (HR) 0.3, 95% CI 0.1-0.9], location (absence of endoanal lesion) of HSILs (HR 0.1, 95% CI 0.01-0.08) and excision of HSILs (HR 3.2, 95% CI 1.1-9.0).
conclusionThe remission of HSILs was not a frequent event in this long-term cohort study. HPV16 is a pejorative factor, while other high-risk HPVs are not. Excision of the HSIL, when possible, could be a preferred treatment to allow better remission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.