SynthesisSystematic reviews2025
Ultra-processed foods and risk of all-cause mortality: an updated systematic review and dose-response meta-analysis of prospective cohort studies.
Synthesis in Systematic reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of combined ultra-processed food intake (ultra-processed dietary pattern) with cognitive function impairment: a meta-analysis of prospective cohort studies.Journal of neurology · 2026Pooled it
- Inorganic phosphate: a link between processed food and exercise intolerance in the modern world.Clinical science (London, England : 1979) · 2026Review
- Ultra-Processed Foods and Metabolic Dysfunction: Mechanisms, Clinical Implications, and Public Health Perspectives. Position Paper of the Italian Association of Dietetics and Clinical Nutrition (ADI).Current nutrition reports · 2026Review
- Article
- Reproducibility and Validity of a Nova-Based Food Frequency Questionnaire in Older Italian Adults: The NFFQ-Elderly.Nutrients · 2026Article
- Association Between Ultraprocessed Food Consumption and Cardiovascular Disease Risk: MESA (Multiethnic Study of Atherosclerosis).JACC. Advances · 2026Article
- Ultra-Processed Food Consumption and Domain-Specific Quality of Life in Postmenopausal Women: Associations with Mobility and Mental Health.Healthcare (Basel, Switzerland) · 2026Article
- Ultra-Processed Food Consumption and Mental Health and Sleep Quality in Turkish Adults: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Ultra-processed foods and accelerated aging in adults: an emerging public health challenge for nutrition and functional health.Frontiers in nutrition · 2026Review
- The collapse of the food matrix: how ultra-processed foods impact satiety and metabolism by altering physical structure beyond nutrient composition.Frontiers in nutrition · 2026Review
- Ultra-processed food exposure and health outcomes: Current evidence, controversies, and future perspectives.EXCLI journal · 2026Review
- Systematic Review and Meta-Analysis of Quality Claims Associated with Fresh Pet Food: Evaluating Scientific Evidence for Additives, Ingredient Quality, and Effects of Processing in Pet Nutrition.Animals : an open access journal from MDPI · 2025Review
- Large Language Models for Real-World Nutrition Assessment: Structured Prompts, Multi-Model Validation and Expert Oversight.Nutrients · 2025Article
- Review
- Review
- Diet to Data: Validation of a Bias-Mitigating Nutritional Screener Using Assembly Theory.Nutrients · 2025Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundUltra-processed food (UPF) consumption has been steadily increasing globally, yet the associated risk of all-cause mortality remains unclear. We aimed to assess the risk of all-cause mortality of UPFs via an updated systematic review and dose-response meta-analysis.
methodsA comprehensive literature search was conducted in PubMed, Embase, and Cochrane Library for studies published until July 2, 2024, in addition to referred studies included in the previous systematic review. Prospective cohort studies assessing the association between NOVA classification-defined UPF consumption and all-cause mortality were included. Dose-response meta-analysis via a random-effect model was used to combine the results with hazard ratio (HR) as an effect measure.
resultsOverall, 18 studies with 1,148,387 participants (173,107 deaths) were identified. Compared to the lowest, participants with the highest UPF consumption had a 15% increased risk of all-cause mortality (HR = 1.15, 95% CI 1.09-1.22; I
conclusionsOur updated meta-analysis, incorporating a greater number of newly published cohort studies using NOVA classification with the largest sample size to date, strengthens the evidence linking higher UPF consumption to increased all-cause mortality risk. Strategies such as dietary guidelines and policies for limiting UPF consumption worldwide should be encouraged. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42023467226.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.