Evidence map›Paper›PMID 40033442›Full record

ArticleMolecular brain2025

Quercetin carbon quantum dots: dual-target therapy for intracerebral hemorrhage in mice.

Guangyu Jia, Xinyu Yang, Yamei Yu, Yuanyuan Li, Zhe Zhang, Xiaolong Tang, Qi Wang, Heqing Zheng, Yao Xiao, Shiyong Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Nanobiotechnologies for stroke treatment.Nanomedicine (London, England) · 2025
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Guangyu Jia *Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Xinyu Yang *Department of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Yamei Yu *Department of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Yuanyuan LiInstitute of Neuroscience, Nanchang University, Nanchang, Jiangxi, 330006, China.
Zhe ZhangDepartment of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Xiaolong TangDepartment of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Qi WangDepartment of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Heqing ZhengDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China.
Yao XiaoDepartment of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. 403007220033@email.ncu.edu.cn.
Shiyong LiDepartment of Neurosurgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. sylicg@ncu.edu.cn.
Ye WangDepartment of Neurology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, China. ndefy08041@ncu.edu.cn.

Funding

Academic and Technical Leaders of Key Disciplines in Jiangxi Province Cultivation Program - Leading Talent Project 20204BCJL22050Academic and Technical Leaders of Key Disciplines in Jiangxi Province Cultivation Program - Leading Talent Project 20213BCJ22012Innovative Research Group Project of the National Natural Science Foundation of China 82060254Innovative Research Group Project of the National Natural Science Foundation of China 82171335Natural Science Foundation of Jiangxi Province 20224ACB206017
6 · The paper itself

Abstract

Following intracerebral hemorrhage, mitigating oxidative stress and removing excess iron are critical strategies for reducing secondary brain injury and improving neurological outcomes. In vitro, we synthesized quercetin-ethylenediamine carbon quantum dots (QECQDs) with diameters of 2-11 nm and found that QECQDs effectively scavenge ABTS+· and DPPH· free radicals, defending HT22 cells against hemin-induced oxidative stress. In vivo, QECQDs predominantly accumulate in the pia mater, subarachnoid space, and dura mater after intrathecal injection. Compared to the ICH injury group, QECQDs treatment effectively improves cerebral blood flow, inhibits oxidative stress damage, and reduces neuron death. Importantly, QECQDs treatment reduced hemorrhage volume, alleviated edema, and improved neurological function. This lays a foundation for developing multi-target drugs for treating ICH.

Indexed as

CarbonCerebral HemorrhageMolecular Targeted TherapyQuantum DotsQuercetinAnimalsBrain EdemaCell DeathCell LineCerebrovascular CirculationHeminMaleMiceNeuronsOxidative StressCarbonHeminQuercetinCarbon quantum dotsIntracerebral hemorrhageIron overloadOxidative stressQuercetin

Identifiers

PMID40033442
PMCPMC11874443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.