Evidence map›Paper›PMID 40033384›Full record

ArticleCell communication and signaling : CCS2025

Lysine 2-hydroxyisobutyrylation of HXK1 alters energy metabolism and K

Hai-Tao Hou, Xiang-Chong Wang, Huan-Xin Chen, Jun Wang, Qin Yang, Guo-Wei He

Abstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hai-Tao Hou *Institute of Cardiovascular Diseases, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences & Peking Union Medical College, No.61, 3rd Ave, TEDA, Tianjin, 300457, China.
Xiang-Chong Wang *Institute of Cardiovascular Diseases, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences & Peking Union Medical College, No.61, 3rd Ave, TEDA, Tianjin, 300457, China.
Huan-Xin ChenInstitute of Cardiovascular Diseases, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences & Peking Union Medical College, No.61, 3rd Ave, TEDA, Tianjin, 300457, China.
Jun WangInstitute of Cardiovascular Diseases, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences & Peking Union Medical College, No.61, 3rd Ave, TEDA, Tianjin, 300457, China.
Qin YangInstitute of Cardiovascular Diseases, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences & Peking Union Medical College, No.61, 3rd Ave, TEDA, Tianjin, 300457, China.
Guo-Wei HeInstitute of Cardiovascular Diseases, Department of Cardiovascular Surgery, TEDA International Cardiovascular Hospital, Tianjin University & Chinese Academy of Medical Sciences & Peking Union Medical College, No.61, 3rd Ave, TEDA, Tianjin, 300457, China. gwhezj@163.com.

Funding

China Postdoctoral Science Foundation 2021M692374Chinese Academy of Medical Sciences 2020-PT310-007 & 2019XK310001National Natural Science Foundation of China 82170353 & 82370350 & 81870288Tianjin Municipal Science and Technology Bureau 21JCYBJC01120
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is the most common form of arrhythmia and is a growing clinical problem. Post-translational modifications (PTMs) constitute crucial epigenetic mechanisms but modification of lysine 2-hydroxyisobutyrylation (K

methodsPTM proteomics was applied in the human atrial tissue from AF and sinus rhythm patients with heart valve disease during cardiac surgery to identify the K

resultsThe modification of 124 K

conclusionsThis study demonstrates the importance of K

Indexed as

Atrial FibrillationEnergy MetabolismHeart AtriaHexokinaseKATP ChannelsLysineAction PotentialsFemaleHumansMaleMiddle AgedProtein Processing, Post-TranslationalHexokinaseKATP ChannelsLysine2-hydroxyisobutyrylationAcylationAtrial fibrillationCatalysisPost-translational modification

Identifiers

PMID40033384
PMCPMC11874433

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.