Evidence map›Paper›PMID 40033359›Full record

ReviewJournal of nanobiotechnology2025

Multidimensional applications of prussian blue-based nanoparticles in cancer immunotherapy.

Jiayi Zhang, Fang Wang, Zhaogang Sun, Jun Ye, Hongqian Chu

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Emerging copper-based hollow nanoplatforms for cancer treatment.International journal of pharmaceutics: X · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jiayi ZhangTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
Fang WangTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
Zhaogang SunTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
Jun YeState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China. yelinghao@imm.ac.cn.
Hongqian ChuTranslational Medicine Center, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China. chuhongqian@bjxkyy.cn.

Funding

Beijing Municipal Administration of Hospitals' Incubating Programme PX2021061Beijing Municipal Administration of Hospitals' Youth Programme QML20231601National Natural Science Foundation 82304393Tongzhou District Health Development Research Reserve Project Foundation KJ2024CX024
6 · The paper itself

Abstract

Immunotherapy holds notable progress in the treatment of cancer. However, the clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as a revolutionary tool to surmount these obstacles and amplify the potency of immunotherapeutic agents. Prussian blue nanoparticles (PBNPs) exhibit multi-dimensional immune function in cancer immunotherapy, including acting as a nanocarrier to deliver immunotherapeutic agents, as a photothermal agent to improve the efficacy of immunotherapy through photothermal therapy, as a nanozyme to regulate tumor microenvironment, and as an iron donor to induce immune events related to ferroptosis and tumor-associated macrophages polarization. This review focuses on the advances and applications of PBNPs in cancer immunotherapy. First, the biomedical functions of PBNPs are introduced. Then, based on the immune function of PBNPs, we systematically reviewed the multidimensional application of PBNPs in cancer immunotherapy. Finally, the challenges and future developments of PBNPs-based cancer immunotherapy are highlighted.

Indexed as

FerrocyanidesImmunotherapyNanoparticlesNeoplasmsAnimalsHumansTumor Microenvironmentferric ferrocyanideFerrocyanidesCancer immunotherapyFerroptosisNanoparticlesNanozymePhotothermal therapyPrussian blue

Identifiers

PMID40033359
PMCPMC11874808

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.