Evidence map›Paper›PMID 40033337›Full record

ArticleJournal of experimental & clinical cancer research : CR2025

NONO regulates m

Gaichao Zhao, Ruochen Liu, Lingjun Ge, Dan Qi, Qishu Wu, Zini Lin, Houji Song, Liping Zhong, Hongjuan Cui

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. mBiology direct · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. The Role of Methylation Modification in Neural Injury and Repair.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gaichao ZhaoState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Ruochen LiuState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Lingjun GeState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Dan QiState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Qishu WuState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Zini LinState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Houji SongState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China.
Liping ZhongState Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning, 530021, Guangxi, China. zhong_liping@163.com.
Hongjuan CuiState Key Laboratory of Resource Insects, Medical Research Institute, Southwest University, Chongqing, 400716, China. hcui@swu.edu.cn.ORCID http://orcid.org/0000-0003-1178-1570

Funding

National Natural Science Foundation project NO.82104654Natural Science Foundation of Chongqing cstc2019jcyj-zdxmX0033Natural Science Foundation of Chongqing cstc2022ycjh-bgzxm0145
6 · The paper itself

Abstract

backgroundThe effect of m

methodsWe analyzed tissue microarrays and transcriptomic data derived from gastric cancer, with an emphasis on RNA splicing and m

resultsAnalysis of publicly available datasets and immunohistochemistry assay of tissue microarrays containing 40 GC tissues showed NONO was upregulated in GC and contributed to poor prognosis. In vitro and in vivo experiments indicated a positive regulatory role of NONO in terms of cell proliferation, migration, and invasion of GC. Mechanically, NONO interacted directly with PTEN pre-mRNA and recruited the RNA m

conclusionHere, we revealed NONO-regulated AS of PTEN mRNA in an m

Indexed as

Alternative SplicingPTEN PhosphohydrolaseRNA, MessengerStomach NeoplasmsAnimalsCell Line, TumorCell ProliferationDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMicePTEN PhosphohydrolasePTEN protein, humanRNA, MessengerAlternative splicingGCm5CNONONSUN2PTEN

Identifiers

PMID40033337
PMCPMC11877715

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.