Evidence map›Paper›PMID 40033283›Full record

ArticleBMC medical imaging2025

Comparison of the value of FAPI imaging and speckle‑tracking echocardiography in assessment of right ventricular remodeling in pulmonary hypertension.

Bi-Xi Chen, Huimin Hu, Juanni Gong, Xiao-Ying Xi, Yaning Ma, Yuanhua Yang, Min-Fu Yang, Yidan Li

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bi-Xi Chen *Department of Nuclear Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.
Huimin Hu *Department of Department of Echocardiography, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.
Juanni GongDepartment of Respiratory and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.
Xiao-Ying XiDepartment of Nuclear Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.
Yaning MaDepartment of Department of Echocardiography, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.
Yuanhua YangDepartment of Respiratory and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China.
Min-Fu YangDepartment of Nuclear Medicine, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China. minfuyang@126.com.ORCID 0000-0002-9561-9003
Yidan LiDepartment of Department of Echocardiography, Beijing Institute of Respiratory Medicine, Beijing Chao-Yang Hospital, Capital Medical University, 8th Gongtinanlu Rd, Chaoyang District, Beijing, 100020, China. yidan_li@163.com.ORCID 0000-0002-9015-0541

Funding

Beijing Chao-Yang Hospital Golden Seeds Fundation CYJZ202207Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZYLX202105Beijing Municipal Science and Technology Commission, Adminitrative Commission of Zhongguancun Science Park Z221100007422028National Natural Science Foundation of China 81871356National Natural Science Foundation of China 81871380Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202303Reform and Development Program of Beijing Institute of Respiratory Medicine Ggyfz202307
6 · The paper itself

Abstract

purposesThis retrospective study was designed to explore the relationship between right ventricular fibroblast activation measured by fibroblast activation protein inhibitor (FAPI) imaging and myocardial deformation measured by Speckle‑tracking Echocardiography (STE) in patients with pulmonary hypertension (PH).

methodsClinical data of PH patients were collected [15 chronic thromboembolic pulmonary hypertension (CTEPH), 4 PAH, 1 PH with unclear and/or multifactorial mechanisms]. All of patients underwent FAPI imaging and echocardiography within one month. FAPI activity of right ventricle higher than that in the blood pool was defined as abnormal. The global and segmental maximum standardised uptake values (SUV

resultsEighteen patients with PH showed abnormal FAPI uptake in right ventricle. No significant differences were found between CTEPH and other types of PH. TBR of right ventricle had negative correlations with RVGLS (r = -0.597, P = 0.005) and RVFWLS (r = -0.586, P = 0.007) at global level. While, at regional level, significant correlation was only demonstrated between TBR of right ventricle free wall and RVFWLS in apical region (r = -0.530, P = 0.016) and middle region (r = -0.457, P = 0.043). Among the traditional Echocardiography parameters, TBR of right ventricle were positively associated with thickness of right ventricular anterior wall (RVAW) (r

conclusionFAPI imaging can partially reflect the right ventricular strain reduction in patients with PH.

Indexed as

EchocardiographyHypertension, PulmonaryVentricular Dysfunction, RightVentricular RemodelingAdultAgedEndopeptidasesFemaleFibroblast Activation Protein AlphaHeart VentriclesHumansMaleMembrane ProteinsMiddle AgedReproducibility of ResultsRetrospective StudiesEndopeptidasesFibroblast Activation Protein AlphaMembrane ProteinsEchocardiographyFAPIPulmonary hypertensionSpeckle tracking

Identifiers

PMID40033283
PMCPMC11874803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.