SynthesisBMC cancer2025
Efficacy and safety of PD-1/PD-L1 inhibitors for natural killer/T-cell lymphoma: a single-arm meta-analysis.
Synthesis in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and Safety of Immune Checkpoint Inhibitors in the Treatment of Hematologic Malignancies: An Umbrella Review of Systematic Reviews and Meta-Analyses.Cancer medicine · 2026Pooled it
- Liposomal mitoxantrone plus tislelizumab in patients with relapsed or refractory extranodal natural killer/T-cell lymphoma: a phase 1b/2 trial.Nature communications · 2026Trial
- Real-World Outcomes of Frontline Multimodal Treatment Strategies for Localized Extranodal NK/T-Cell Lymphoma, Nasal Type: A Single-Center Vietnamese Cohort Study.Current oncology (Toronto, Ont.) · 2026Article
- The increased co-expression of SLC7A11 and PD-L1 was associated with poor prognosis in extranodal natural killer T-cell lymphoma patients.Cancer immunology, immunotherapy : CII · 2026Article
- Immune Checkpoint Blockade in Hematological Malignancies: Current Status and Future Directions.Cancers · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the advent of asparaginase-based drugs, patients with natural killer/T-cell lymphoma (NKTCL) have achieved excellent efficacy. However, the prognosis is poor in patients with advanced disease, and even worse in relapse/refractory patients. This meta-analysis aimed to evaluate the efficacy and safety of PD-1/PD-L1 inhibitor monotherapy or combination treatment strategies in patients with NKTCL.
methodSeven databases were extensively searched from inception to November 2023 and updated in April 2024, with no language restrictions. The pooled overall response rate (ORR), overall survival (OS), progression-free survival (PFS), and treatment-related adverse events (AEs) were calculated via a random effects model. Heterogeneity was tested utilizing the I-square (I
resultsA total of thirteen single-arm studies involving 460 patients were enrolled. The results revealed that the pooled ORR was 62% (95% CI: 48-76%). In terms of survival outcomes, the pooled 1-year OS was 67% (95% CI: 47-87%) and the 2-year OS was 47% (95% CI: 24-69%). Moreover, the 1-year and 2-year PFS rates were 66% (95% CI: 48-84%) and 59% (95% CI: 34-84%), respectively. With regard to treatment toxicity, the pooled incidence of all-grade AEs was 86% (95% CI: 79-93%), and the pooled incidence of grade 3 or higher AEs was 29% (95% CI: 22-36%). Leukopenia and hypoalbuminemia were identified as the most common hematologic and non-hematologic adverse events, respectively.
conclusionEvidence suggests that PD-1/PD-L1 inhibitors are promising treatment options for newly diagnosed NKTCL patients. PD-1/PD-L1 inhibitors combined with chemotherapy or chidamide has demonstrated superior clinical efficacy in patients with relapsed/refractory NKTCL. TRIAL REGISTERATION: Open Science Framwork: osf.io/2bwh3.
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