SynthesisBMC cardiovascular disorders2025
The link between adherence to antihypertensive medications and mortality rates in patients with hypertension: a systematic review and meta-analysis of cohort studies.
Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of medication adherence and mortality in chronic disease: Implications for clinical guidelines and policy.British journal of clinical pharmacology · 2026Pooled it
- Artificial intelligence-based chatbots to enhance medication adherence among patients with non-communicable chronic diseases: Systematic review and meta-analysis.PLOS digital health · 2026Article
- Healthcare professionals' perspectives on medication adherence-supporting tools: a cross‑sectional survey in Italy.European journal of clinical pharmacology · 2026Article
- Associations between social determinants and poor hypertension treatment adherence among middle-aged and older people in rural China: a hospital-based case‒control study.BMC public health · 2026Article
- Article
- Prescribing Trends of Antihypertensive Medications: An Observational Study in a Tertiary Care Hospital in India.Cureus · 2026Article
- Assessment of the quality and reliability of public health communication about hypertension on short video platforms in China.Frontiers in public health · 2026Article
- Impact of Antihypertensive Treatment Adherence on Premature Mortality over Seven Years: A Follow-Up Investigation.Journal of clinical medicine · 2025Article
- Impact of pooled procurement of medicines on patient adherence and economic burden: evidence from China.Journal of global health · 2025Article
- Forgetfulness to Take Antihypertensive Medications and Poor Blood Pressure Control in Older Adults With Type 2 Diabetes and Hypertension in Vietnam.Journal of clinical hypertension (Greenwich, Conn.) · 2025Observational
- Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Development and Validation of Predictive Models for Non-Adherence to Antihypertensive Medication.Medicina (Kaunas, Lithuania) · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension (HTN) significantly contributes to cardiovascular disease (CVD) and mortality. This systematic review and meta-analysis specifically investigates how different levels of adherence to antihypertensive therapy (AHT) affect mortality rates in HTN patients. By synthesizing cohort studies, it aims to enhance understanding and inform clinical practices to improve outcomes in hypertensive populations.
methodsOur meta-analysis employed a comprehensive search strategy using keywords related to hypertension, medical adherence, and mortality across PubMed, Scopus, and Web of Science, up to July 2024. The eligibility criteria focused on cohort studies linking AHT adherence to mortality. The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias (ROB). Quantitative analyses involved hazard ratios (HR) and confidence intervals (CI), with an 80% adherence threshold. Subgroup and meta-regression analyses were also conducted using STATA-17 to explore various outcome factors.
resultsFrom initial 1,999 studies 12 cohort studies included in our analysis. All included studies had low ROB score. A meta-analysis of 12 studies involving 2,198,311 patient with HTN revealed that poor adherence to treatment significantly increased all-cause mortality (HR: 1.32 [1.14, 1.51], p < 0.001) with high heterogeneity (I²: 98.73%). Additionally, an analysis of four studies with 1,695,872 patients indicated that low adherence was linked to elevated cardiovascular mortality (HR: 1.61 [1.43, 1.78], p < 0.001), showing moderate heterogeneity (I²: 49.51%).
conclusionsThe study found that poor adherence to AHT significantly increases overall and cardiovascular mortality risk, underscoring the need for improved compliance strategies. Limitations like inconsistent definitions, observational biases, and varying follow-up durations necessitate further research to validate these findings. CLINICAL TRIAL NUMBER: Not applicable.
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