Evidence map›Paper›PMID 40033218›Full record

ArticleBMC nephrology2025

Overexpression of plasmalemmal vesicle-associated protein-1 in patient with cyanotic nephropathy: a case report.

Yusuke Ushio, So Hirata, Shun Manabe, Mayuko Suyama, Ayano Tanaka, Momoko Seki, Haruka Kato, Kana Nomura, Anna Nakai, Hitoko Sumori and 8 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yusuke UshioDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan. ushio.yusuke@twmu.ac.jp.
So HirataDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Shun ManabeDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Mayuko SuyamaDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Ayano TanakaDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Momoko SekiDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Haruka KatoDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Kana NomuraDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Anna NakaiDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Hitoko SumoriDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Yuki KawaguchiDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Shizuka KobayashiDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Shiho MakabeDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Hiroshi KataokaDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.
Naoko ItohDepartment of Surgical Pathology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, , Tokyo, Japan.
Sekiko TanedaDepartment of Surgical Pathology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, , Tokyo, Japan.
Kazuho HondaDepartment of Anatomy, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan.
Junichi HoshinoDepartment of Nephrology, Tokyo Women'S Medical University, 8-1, Kawada-Cho, Shinjuku-Ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyanotic nephropathy (CN) is a known complication of cyanotic congenital heart disease (CCHD). However, many aspects of its pathophysiology remain unclear. CASE PRESENTATION: We report the case of a 29-year-old male with a history of tetralogy of Fallot. Renal biopsy revealed glomerular hypertrophy and focal segmental glomerulosclerosis. Electron microscopy revealed extensive endothelial cell damage. To investigate the etiology of endothelial cell damage, PAL-E staining was conducted, revealing staining along the glomerular capillary wall.

conclusionThis is the first report of PAL-E staining in CN, suggesting potential overexpression of PV-1. The association of PV-1 expression with endothelial cell damage indicates its role in the pathogenesis of CN.

Indexed as

CyanosisKidney DiseasesMembrane ProteinsTetralogy of FallotAdultGlomerulosclerosis, Focal SegmentalHumansKidney GlomerulusMaleMembrane ProteinsCase reportCyanotic congenital heart diseaseCyanotic nephropathyPAL-E

Identifiers

PMID40033218
PMCPMC11874792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.