ArticleBMC neuroscience2025
Visualization of perivascular spaces in the human brain with 5-T magnetic resonance imaging.
Article in BMC neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Post-gadolinium T1 alterations in Parkinson's disease and essential tremor.NPJ Parkinson's disease · 2026Article
- Grading of glioma and prediction of IDH mutation status via longitudinal relaxation time in rotating frame mapping on 5-T magnetic resonance imaging: added value to amide proton transfer-weighted imaging.Quantitative imaging in medicine and surgery · 2026Article
- Detection of perivascular spaces at the gray-white matter interface using heavily TNeuroImage · 2026Article
- Clinical evaluation of femoral head cartilage damage using 5-Tesla MRI T2-mapping sequence-based on pathological specimens.BMC musculoskeletal disorders · 2026Article
- "Mind the Gap"-enlarged perivascular spaces as a potential magnetic resonance imaging biomarker of impaired glymphatic clearance in brain disorders.Frontiers in cellular neuroscience · 2026Review
- Reconsideration of the DTI-ALPS index as a glymphatic surrogate: disease-specific findings in small vessel disease due to cerebral amyloid angiopathy or arteriolosclerosis.Frontiers in aging neuroscience · 2026Article
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11 authors.
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Abstract
backgroundTo evaluate the effectiveness of 5-Tesla (T) magnetic resonance imaging (MRI) in the visualization of perivascular spaces (PVS).
methodA total of seventeen subjects underwent three-dimensional (3D) T1- and T2-weighted imaging on both 3-T and 5-T MRI systems. Twelve of these subjects underwent quantitative analysis of PVS in the semioval center (SOC) and basal ganglia (BG), with comparisons made between the two systems using paired-sample Wilcoxon tests. Additionally, high-resolution 5-T images were acquired for five other participants to examine the detailed anatomy of PVS in the SOC, BG, and cerebral cortex.
resultsCompared with 3-T MRI, 5-T MRI detected more PVS in the SOC and BG [39.5 (32.0-63.0) vs. 56.5 (44.0-75.5) and 49.5 (27.0-55.8) vs. 65.5 (53.0-72.0)] with p-values of 0.002 and 0.004, respectively. In these two regions, the PVS tortuosity, defined as the ratio of the actual path length to the straight-line distance between the start and end points of the PVS, was lower at 3-T compared to 5-T (p = 0.012 for the SOC and p = 0.006 for the BG). The length of PVS in the SOC on 5-T was longer than those on 3-T [4.6 mm (3.9-6.3 mm) vs. 5.1 mm (4.6-6.7 mm), p = 0.049]. In addition, the 5-T MRI provided enhanced visualization of the morphology of PVS in vivo, and improved the depiction of PVS across various brain regions, especially in the cortex, illustrating their course and associated small vessels.
conclusions5-T MRI notably enhanced the visualization of PVS compared to 3-T, particularly in its ability to depict PVS anatomy in the cortex using high-resolution images. This advancement may pave the way for further research into the physiological roles of PVS and their involvement in related diseases.
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