Evidence map›Paper›PMID 40033185›Full record

ArticleBMC gastroenterology2025

Prevalence of oral manifestations in coeliac disease and associated factors.

Jani Manninen, Saana Paavola, Kalle Kurppa, Heini Huhtala, Teea Salmi, Katri Kaukinen, Camilla Pasternack

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jani ManninenCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Saana PaavolaCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kalle KurppaCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Heini HuhtalaFaculty of Social Sciences, Tampere University, Tampere, Finland.
Teea SalmiCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Katri KaukinenCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Camilla PasternackCeliac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. camilla.pasternack@tuni.fi.

Funding

State Funding for University-Level Health Research, Tampere University Hospital, the Wellbeing Services County of Pirkanmaa T62834
6 · The paper itself

Abstract

backgroundVarious oral manifestations are associated with coeliac disease in children, whereas data on adults are scarce. Moreover, possible individual factors predisposing to these manifestations remain unresolved. The aim of this study was to investigate these issues in a large cohort of adult coeliac disease patients both at diagnosis and while on gluten-free diet (GFD).

methodsThis population-based study involved 873 adult patients with coeliac disease and 563 non-coeliac controls. Patients and controls were interviewed and structured questionnaires were used to assess the severity of gastrointestinal symptoms and quality of life at the time of the study. All participants were systematically asked about oral manifestations, including dental enamel defects, recurrent aphthous ulceration and glossodynia. Coeliac disease-related data were collected from medical records. Possible individual factors associated with oral manifestations were studied using logistic regression analysis.

resultsDental enamel defects were more common among patients than among non-coeliac controls (27% vs. 4%, p < 0.001). Prior to the coeliac disease diagnosis, 56% of the patients had experienced recurrent aphthous ulceration and GFD brought relief to 69% of them. While on GFD, coeliac disease patients had higher prevalence of recurrent aphthous ulceration than did the controls (17% vs. 13%, p = 0.040), but this significance disappeared after adjusting for gender. Glossodynia on GFD was more prevalent in the coeliac cohort than in the controls (14% vs 6%, p < 0.001). Oral manifestations at diagnosis and on GFD were associated with the presence of abdominal symptoms at the time of coeliac disease diagnosis, long diagnostic delay and female gender. At the time of the study, patients with oral symptoms had more severe gastrointestinal symptoms and poorer quality of life than those without these symptoms.

conclusionsOral manifestations were more prevalent, at diagnosis and on GFD, in patients with coeliac disease than in the controls, and they were associated with long diagnostic delay, abdominal symptoms, female gender and impaired quality of life. A GFD was shown beneficial in relieving recurrent aphthous ulcerations in patients with coeliac disease.

Indexed as

Celiac DiseaseMouth DiseasesStomatitis, AphthousAdultAgedCase-Control StudiesDiet, Gluten-FreeFemaleHumansMaleMiddle AgedPrevalenceQuality of LifeYoung AdultAphthous ulcersCoeliac diseaseDental enamel defectsGlossodyniaGluten-free dietOral manifestationsOral symptomsRecurrent aphthous stomatitis

Identifiers

PMID40033185
PMCPMC11874438

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.