Evidence map›Paper›PMID 40033162›Full record

ArticleLasers in surgery and medicine2025

Comparison of Topical 5-Aminolevulinic Acid Photodynamic Therapy With the Loop Electrosurgical Excision Procedure for Patients With Cervical High-Grade Squamous Intraepithelial Neoplasia: A Prospective and Propensity-Matched Analysis.

Yao Yang, Bingying Sun, Dan Cao, Ying Xu, Yi Chen, Dan Wu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yao YangInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.ORCID http://orcid.org/0009-0003-4127-6919
Bingying SunInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dan CaoInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ying XuInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yi ChenInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dan WuInternational Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

This work was supported by the Technology Transfer Project of Shanghai Jiao Tong University School of Medicine (Grant ZT202309), the Shanghai Shenkang Medical Development Center Project (Grant SHDC12023119), Shanghai Jiao Tong University 'Star of Jiao Tong University' Programme Medical-Industrial Intersection Research Fund (Grant TG2025ZD28), and Three-Year Action Plan for Clinical Research Capacity Enhancement of the China Welfare Institute International Peace Maternity and Child Health Centre (Grant IPMCH2024CR05).
6 · The paper itself

Abstract

objectiveTo evaluate the efficacy of 5-aminolevulinic acid photodynamic therapy (PDT) for high-grade squamous intraepithelial lesions of the cervix associated with high-risk human papillomavirus (HPV) infection.

methodsIn this study, 120 patients who received treatment for high-grade squamous intraepithelial lesions of the cervix from March 2023 to March 2024 were followed up prospectively, which were categorized into the PDT and loop electrosurgical excision procedure (LEEP) groups and matched 1:1 using a propensity score. The regression rate of the lesions and the HPV clearance rate were compared between the groups at 6 and 12 months. Factors affecting the clearance rate were analyzed.

resultsAt the 6- and 12-month follow-ups, no significant difference was observed in the rate of lesion regression between the PDT (86.7%, 91.7%) and LEEP groups (85.0%, 93.3%) (p > 0.05), nor the HPV clearance rate (55.0%, 76.7% vs. 65.0%, 78.3%) (p > 0.05). Neither group had any lesions that progressed to Grade 3 or invasive cervical carcinoma at follow-up. According to regression analysis, thinprep cytology test (TCT) results influenced lesion regression in the PDT group.

conclusionCompared to the LEEP, 5-aminolevulinic acid PDT had a similar rate of lesion regression and HPV clearance for the treatment of high-grade squamous intraepithelial lesions of the cervix; thus, PDT offers an alternative and effective minimally invasive approach.

Indexed as

Aminolevulinic AcidElectrosurgeryPhotochemotherapyPhotosensitizing AgentsSquamous Intraepithelial Lesions of the CervixUterine Cervical DysplasiaUterine Cervical NeoplasmsAdministration, TopicalAdultFemaleFollow-Up StudiesHumansMiddle AgedPapillomavirus InfectionsPropensity ScoreProspective StudiesAminolevulinic AcidPhotosensitizing Agents

Identifiers

PMID40033162
PMCPMC11950667

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