Evidence map›Paper›PMID 40033139›Full record

ArticleCommunications biology2025

Invariant NK T cells counteract HCC metastasis by mediating the migration of splenic CD4

Jinke Geng, Mengxiao Xie, Meina Yan, Xiaoyan Xie, Fuxin Wang, Rui Zhu, Mutian Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. CCR1Journal of advanced research · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jinke Geng *Center for Medical Laboratory Science, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Mengxiao Xie *Department of Laboratory Medicine, Jiangsu Province Hospital, Nanjing, Jiangsu, China.
Meina YanCenter for Medical Laboratory Science, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Xiaoyan XieCenter for Medical Laboratory Science, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Fuxin WangCenter for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China.
Rui ZhuCenter for Human Reproduction and Genetics, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China. zhurui2528@njmu.edu.cn.ORCID http://orcid.org/0000-0001-6094-2639
Mutian HanCenter for Medical Laboratory Science, Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu, China. Jiopkuy@aliyun.com.ORCID http://orcid.org/0000-0002-2456-4893

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82101902National Natural Science Foundation of China (National Science Foundation of China) 82271696Natural Science Foundation of Jiangsu Province (Jiangsu Provincial Natural Science Foundation) BK20201079
6 · The paper itself

Abstract

Despite significant advances in the diagnosis and treatment of hepatocellular carcinoma (HCC), metastasis and recurrence remain two major obstacles to improving the clinical outcomes for HCC patients. Here, we demonstrate that splenic invariant natural killer T (iNKT) cells can significantly inhibit Hepa1-6-mediated intrahepatic HCC metastasis. Interestingly, in the HCC metastasis model, iNKT deficiency can result in a significant decrease in percentage and absolute number of CD4

Indexed as

B-LymphocytesCarcinoma, HepatocellularCD4-Positive T-LymphocytesCell MovementLiver NeoplasmsNatural Killer T-CellsSpleenAnimalsCell Line, TumorHumansInterferon-gammaMaleMiceMice, Inbred C57BLNeoplasm MetastasisInterferon-gamma

Identifiers

PMID40033139
PMCPMC11876620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.