Evidence map›Paper›PMID 40033130›Full record

ArticleNPJ digital medicine2025

Assessing and alleviating state anxiety in large language models.

Ziv Ben-Zion, Kristin Witte, Akshay K Jagadish, Or Duek, Ilan Harpaz-Rotem, Marie-Christine Khorsandian, Achim Burrer, Erich Seifritz, Philipp Homan, Eric Schulz and 1 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziv Ben-ZionDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA. ziv.ben-zion@yale.edu.ORCID http://orcid.org/0000-0003-3629-5851
Kristin Witte *Helmholtz Institute for Human-Centered Artificial Intelligence, Munich, Germany.
Akshay K Jagadish *Helmholtz Institute for Human-Centered Artificial Intelligence, Munich, Germany.
Or DuekDepartment of Epidemiology, Biostatistics, and Community Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.ORCID http://orcid.org/0000-0001-5211-7946
Ilan Harpaz-RotemDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Marie-Christine KhorsandianPsychiatric University Clinic Zurich (PUK), Zurich, Switzerland.
Achim BurrerPsychiatric University Clinic Zurich (PUK), Zurich, Switzerland.
Erich SeifritzPsychiatric University Clinic Zurich (PUK), Zurich, Switzerland.
Philipp HomanPsychiatric University Clinic Zurich (PUK), Zurich, Switzerland.ORCID http://orcid.org/0000-0001-9034-148X
Eric SchulzHelmholtz Institute for Human-Centered Artificial Intelligence, Munich, Germany.
Tobias R SpillerDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-0107-0743

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

The use of Large Language Models (LLMs) in mental health highlights the need to understand their responses to emotional content. Previous research shows that emotion-inducing prompts can elevate "anxiety" in LLMs, affecting behavior and amplifying biases. Here, we found that traumatic narratives increased Chat-GPT-4's reported anxiety while mindfulness-based exercises reduced it, though not to baseline. These findings suggest managing LLMs' "emotional states" can foster safer and more ethical human-AI interactions.

Identifiers

PMID40033130
PMCPMC11876565

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.