ArticleNature neuroscience2025
Lateral inhibition in V1 controls neural and perceptual contrast sensitivity.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- A standardized and reproducible behavioral framework to elicit multiple aspects of visual spatial attention in mice.Cell reports methods · 2026Article
- Sensory Blurring in Nociplastic Pain: The Role of Descending Inhibitory Dysfunction and Gut-Brain Axis Alterations in Older Adults.Geriatrics (Basel, Switzerland) · 2026Review
- Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs-cAMP Signaling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- A high-dimensional atlas of parvalbumin interneuron soma morphology in mouse visual and somatosensory cortex.Frontiers in neuroscience · 2026Article
- Article
- Circuit dynamics of binocular conflict in mouse primary visual cortex.Frontiers in systems neuroscience · 2026Article
- A standardized and reproducible behavioral protocol to elicit visual spatial attention in mice.bioRxiv : the preprint server for biology · 2025Article
- A genetic algorithm for self-supervised models of oscillatory neurodynamics.bioRxiv : the preprint server for biology · 2025Article
- Dissociating instructive from permissive roles of brain circuits with reversible neural activity manipulations.bioRxiv : the preprint server for biology · 2025Article
- Responses to conflicting binocular stimuli in mouse primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Brain-like variational inference.ArXiv · 2025Article
- Layer-specific spatiotemporal dynamics of feedforward and feedback in human visual object perception.bioRxiv : the preprint server for biology · 2025Article
- Highly selective visual receptive fields in mouse frontal cortex.bioRxiv : the preprint server for biology · 2025Article
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13 authors.
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Abstract
Lateral inhibition is a central principle in sensory system function. It is thought to operate by the activation of inhibitory neurons that restrict the spatial spread of sensory excitation. However, the neurons, computations and mechanisms underlying cortical lateral inhibition remain debated, and its importance for perception remains unknown. Here we show that lateral inhibition from parvalbumin neurons in mouse primary visual cortex reduced neural and perceptual sensitivity to visual contrast in a uniform subtractive manner, whereas lateral inhibition from somatostatin neurons more effectively changed the slope (or gain) of neural and perceptual contrast sensitivity. A neural circuit model, anatomical tracing and direct subthreshold measurements indicated that the larger spatial footprint for somatostatin versus parvalbumin synaptic inhibition explains this difference. Together, these results define cell-type-specific computational roles for lateral inhibition in primary visual cortex, and establish their unique consequences on sensitivity to contrast, a fundamental aspect of the visual world.
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